Imatinib in gastrointestinal stromal tumors.

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dc.contributor.authorBakshi, C Aen_US
dc.contributor.authorJain, R Aen_US
dc.contributor.authorSastry, P S R Ken_US
dc.contributor.authorSainani, A Ren_US
dc.contributor.authorAdvani, S Hen_US
dc.date.accessioned2004-05-20en_US
dc.date.accessioned2009-05-30T23:42:48Z
dc.date.available2004-05-20en_US
dc.date.available2009-05-30T23:42:48Z
dc.date.issued2004-05-20en_US
dc.description.abstractGastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of gastrointestinal tract. The tumors express the cell surface transmembrane receptor KIT that has a tyrosine kinase activity and is a protein product of KIT protoeoncogene. These tumors occur in the whole of Gastrointestinal tract. Treatment includes surgical resection for localized tumors. For metastatic disease treatment options include systemic chemotherapy, radiation therapy, with a response rate of less than 10%. Presently Imatinib; a tyrosine kinase inhibitor has shown promising result with response rates upto 59-69% in phase II results in metastatic setting; and ongoing phase II & phase III trials in adjuvant setting will help to establish its role as an adjuvant to surgery. We have treated eleven patients of metastatic GIST with Imatinib and we hereby present these cases.en_US
dc.description.affiliationJaslok Hospital and Research Centre, 15 G Deshmukh Marg, Mumbai.en_US
dc.identifier.citationBakshi CA, Jain RA, Sastry PS, Sainani AR, Advani SH. Imatinib in gastrointestinal stromal tumors. Journal of the Association of Physicians of India. 2004 May; 52(): 403-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/90667
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Agents --therapeutic useen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Stromal Tumors --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPiperazines --therapeutic useen_US
dc.subject.meshPyrimidines --therapeutic useen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleImatinib in gastrointestinal stromal tumors.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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