Cardiovascular responses to phenylephrine during acute experimental anaemia in anaesthetized cats.

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dc.contributor.authorTalwar, Aen_US
dc.contributor.authorHussain, M Een_US
dc.contributor.authorGupta, C Ken_US
dc.contributor.authorFahim, Men_US
dc.date.accessioned1995-04-01en_US
dc.date.accessioned2009-06-01T05:10:44Z
dc.date.available1995-04-01en_US
dc.date.available2009-06-01T05:10:44Z
dc.date.issued1995-04-01en_US
dc.description.abstractExperiments were performed on anaesthetized artificially ventilated cats to study the effects of phenylephrine (PE) on cardiovascular responsiveness, before and after induction of experimental anaemia. Acute anaemia was induced by replacement of blood by dextran in three steps of 20% each of total estimated blood volume. The effect of PE (20 micrograms/kg) was investigated at four stages: control and after 1st, 2nd and 3rd exchanges of blood. Induction of anaemia produced a significant increase in heart rate (HR) and cardiac output (CO) and a decrease in right atrial pressure (RAP). No significant change in mean arterial pressure (MAP), LV dP/dt max and blood gas tension was observed. Administration of bolus dose of PE produced a rapid rise in MAP, LVdP/dt max, and a decrease in HR without a change in the RAP. The pattern of response to PE was similar after induction of acute anaemia, however the magnitude of the response was significantly reduced. The attenuation in the response to PE was related to the fall in the haematocrit (HCT) level. This shows that induction of experimental anaemia, produced an increase in CO due to an increase in HR and SV and the effect of PE on cardiovascular responsiveness was significantly attenuated. The reduced sensitivity to PE during acute anaemia could be due to many factors such as inadequate O2 supply, effect of local vasodilating agents or some other cardiotonic agents which are known to contribute to vascular responsiveness.en_US
dc.description.affiliationDepartment of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi.en_US
dc.identifier.citationTalwar A, Hussain ME, Gupta CK, Fahim M. Cardiovascular responses to phenylephrine during acute experimental anaemia in anaesthetized cats. Indian Journal of Physiology and Pharmacology. 1995 Apr; 39(2): 106-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106413
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAnemia --chemically induceden_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshBlood Substitutes --administration & dosageen_US
dc.subject.meshBlood Volume --drug effectsen_US
dc.subject.meshCardiac Output --drug effectsen_US
dc.subject.meshCatsen_US
dc.subject.meshDextrans --administration & dosageen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshHematocriten_US
dc.subject.meshHemodilution --adverse effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenylephrine --administration & dosageen_US
dc.titleCardiovascular responses to phenylephrine during acute experimental anaemia in anaesthetized cats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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