Epithelial–mesenchymal transition in serous and mucinous epithelial tumors of the ovary

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dc.contributor.authorBhuyan, Geeten_US
dc.contributor.authorArora, Rashmien_US
dc.contributor.authorAhluwalia, Charanjeeten_US
dc.contributor.authorSharma, Preetien_US
dc.date.accessioned2020-11-18T10:07:30Z
dc.date.available2020-11-18T10:07:30Z
dc.date.issued2019-12
dc.description.abstractContext: The concept of epithelial–mesenchymal transition (EMT) in cancer origin, progression, and metastasis is of recent origin and not fully understood. So far, many cell culture studies have been done to investigate the role of EMT in epithelial ovarian cancer, but only a few human studies have been conducted. Aims: The aim of the study is to study the expression of E-cadherin and vimentin in serous and mucinous tumors of the ovary and to compare their expression in benign and malignant serous and mucinous ovarian tumors. Methods: This study was a prospective study done on 60 patients with a histological diagnosis of serous and mucinous ovarian malignancy. The study was conducted in the Department of Pathology and Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. The expression of epithelial marker E-cadherin and mesenchymal marker vimentin was studied in each of the tumors. Statistical Analysis: Unpaired t-test/Mann–Whitney test, Chi-Square test/Fisher's exact test, and Kolmogorov–Smirnov test were used. Results: Of the total 60 cases included in the study, 30 benign and 30 malignant cases of serous and mucinous tumors were taken. Of the 30 benign cases, 22 cases (73.3%) were that of serous cystadenomas, whereas 8 (26.67%) cases were of mucinous cystadenomas. Among the malignant cases, 21 cases (70%) were serous surface epithelial ovarian carcinoma, whereas 9 (30%) were mucinous surface epithelial ovarian carcinoma. Subsequently, the malignant cases were graded according to their glandular differentiation. Immunohistochemistry was performed in each of the 60 cases. Conclusion: In the malignant cases with increasing grade of the tumor, a reduced expression of E-cadherin and an increased expression of vimentin were seen in the epithelial cellsen_US
dc.identifier.affiliationsDepartment of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, Indiaen_US
dc.identifier.citationBhuyan Geet, Arora Rashmi, Ahluwalia Charanjeet, Sharma Preeti. Epithelial–mesenchymal transition in serous and mucinous epithelial tumors of the ovary. Journal of Cancer Research and Therapeutics. 2019 Oct; 15(5): 1309-1315en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213528
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber5en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_35_18en_US
dc.subjectEpithelial–mesenchymal transitionen_US
dc.subjectmucinous tumorsen_US
dc.subjectserous tumorsen_US
dc.titleEpithelial–mesenchymal transition in serous and mucinous epithelial tumors of the ovaryen_US
dc.typeJournal Articleen_US
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