Detection of H. pylori in dyspeptic patients and correlation with clinical outcomes.

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dc.contributor.authorChomvarin, Chariyaen_US
dc.contributor.authorKulsuntiwong, Panthongen_US
dc.contributor.authorMairiang, Pisalnen_US
dc.contributor.authorSangchan, Apichaten_US
dc.contributor.authorKulabkhow, Churairuten_US
dc.contributor.authorChau-in, Sirien_US
dc.contributor.authorWaropastrakul, Nareasen_US
dc.date.accessioned2009-05-27T16:02:23Z
dc.date.available2009-05-27T16:02:23Z
dc.date.issued2005-07-22en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe objectives of this study were to evaluate the methods used to diagnose Helicobacter pylon infection in gastric biopsies, and to evaluate the correlation between H. pylori infection and clinical outcomes. Gastric biopsies, obtained from 210 patients, were evaluated for H. pylori by culture, a commercial rapid urease test (RUT, Pronto Dry) and histological examination. A true positive result was either the culture or both the RUT and histological examination were positive. The results showed a H. pylori infection rate of 44.3% (93/210). The sensitivities, specificities, positive predictive values and negative predictive values were 88.2, 100, 100, and 91.4 % by the culture; 95.7, 98.3, 97.8, and 96.6% by RUT; and 96.8, 59.8, 59.8, and 65.7% by histological examination, respectively. The prevalences of H. pylori in non-ulcer dyspepsia (NUD), peptic ulcer dyspepsia (PUD) and gastric cancer (GCA) patients were 41.2, 57.9 and 70.6%, respectively. The chi-squared-test showed that GCA patients were significantly more frequent infected with H. pylori than NUD patients (p<0.05). Our study indicates that the RUT method was highly sensitive, specific and appropriate for routine clinical use.en_US
dc.description.affiliationDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. chariya@kku.ac.then_US
dc.identifier.citationChomvarin C, Kulsuntiwong P, Mairiang P, Sangchan A, Kulabkhow C, Chau-in S, Waropastrakul N. Detection of H. pylori in dyspeptic patients and correlation with clinical outcomes. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Jul; 36(4): 917-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34271
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2005_36_4/17-3511.pdfen_US
dc.subject.meshDyspepsia --diagnosisen_US
dc.subject.meshEndoscopy, Gastrointestinalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections --diagnosisen_US
dc.subject.meshHelicobacter pylori --isolation & purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailanden_US
dc.titleDetection of H. pylori in dyspeptic patients and correlation with clinical outcomes.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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