Study of the in vitro release profile of sesquiterpenes from a vaginal cream containing Copaifera duckei Dwyer (Fabaceae) oleoresin.
| dc.contributor.author | Carvalho, Helison Oliveira | |
| dc.contributor.author | Lima, Clarissa Silva | |
| dc.contributor.author | Sanches, Anderson Almeid | |
| dc.contributor.author | Silva, Jocivania Oliveira da | |
| dc.contributor.author | Fernandes, Caio Pinho | |
| dc.contributor.author | Carvalho, Jose Carlos Tavares | |
| dc.date.accessioned | 2015-07-06T11:03:32Z | |
| dc.date.available | 2015-07-06T11:03:32Z | |
| dc.date.issued | 2015-04 | |
| dc.description.abstract | Copaiba trees and their oleoresin is an important natural product used as an anti-inflammatory and antimicrobial drug, in particular for gynecological infections. The in vitro release profile of sesquiterpenes in a vaginal cream containing copaiba (CVC – copaiba vaginal cream) oleoresin in buffered solutions at different pHs was evaluated in the present study. The dissolution test revealed that trans-caryophyllene (TC) was constantly released until the final test time. The maximum peaks were found at a concentration of 478.79 nL/mL for the buffer at pH 5 and at a concentration of 475.99 nL/mL for the buffer at pH 6, with a percentage release of 50.52% and 50.21%, respectively. Likewise, the caryophyllene oxide (CO) was released into the buffers at pHs 5 and 6, with maximum release peaks at 60 minutes at a percentage of 31.8% and 33.5% corresponding to concentrations of 2.779 and 2.925 μg/mL, respectively. The release and dissolution profiles of the sesquiterpene compounds indicated that a pH of 5-6 in the dissolution media is adequate for release of these markers of antimicrobial activity in Copaifera duckei Dwyer. Therefore, these conditions possibly favor the therapeutic action of CVC. | en_US |
| dc.identifier.citation | Carvalho Helison Oliveira, Lima Clarissa Silva, Sanches Anderson Almeid, Silva Jocivania Oliveira da, Fernandes Caio Pinho, Carvalho Jose Carlos Tavares. Study of the in vitro release profile of sesquiterpenes from a vaginal cream containing Copaifera duckei Dwyer (Fabaceae) oleoresin. Journal of Applied Pharmaceutical Science. 2015 Mar; 5(4): 1-6. | en_US |
| dc.identifier.issn | 2231-3354 | |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/159158 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.japsonline.com/counter.php?aid=1467 | en_US |
| dc.subject | Copaifera | en_US |
| dc.subject | oleoresin | en_US |
| dc.subject | sesquiterpenes | en_US |
| dc.subject | dissolution | en_US |
| dc.title | Study of the in vitro release profile of sesquiterpenes from a vaginal cream containing Copaifera duckei Dwyer (Fabaceae) oleoresin. | en_US |
| dc.type | Article | en_US |