Wegener's granulomatosis in India: clinical features, treatment and outcome of twenty-five patients.
dc.contributor.author | Kumar, A | en_US |
dc.contributor.author | Pandhi, A | en_US |
dc.contributor.author | Menon, A | en_US |
dc.contributor.author | Sharma, S K | en_US |
dc.contributor.author | Pande, J N | en_US |
dc.contributor.author | Malaviya, A N | en_US |
dc.date.accessioned | 2001-10-10 | en_US |
dc.date.accessioned | 2009-05-27T10:11:04Z | |
dc.date.available | 2001-10-10 | en_US |
dc.date.available | 2009-05-27T10:11:04Z | |
dc.date.issued | 2001-10-10 | en_US |
dc.description.abstract | OBJECTIVE: To report our clinical experience on Wegener's granulomatosis (WG). METHODS: A retrospective review of case records of all patients with WG in our Rheumatology Clinic during the period July 1988 to June 2000 was carried out and the details of demography, clinical and laboratory data, treatment and outcome were obtained and analysed. RESULTS: Twenty-five patients (16 females and 9 males) were found eligible for inclusion in the study. The mean age and duration of symptoms at presentation were 33.5 years and 5.5 months, respectively. Two patients had limited WG. Twenty-two patients with generalized WG were treated with standard regimen comprising oral prednisolone (1 mg/kg/day) and oral cyclophosphamide (2 mg/kg/day). Cyclophosphamide was continued for at least one year after the patient attained remission. One patient was treated with intravenous cyclophosphamide regimen. The two patients with limited WG were treated with oral prednisolone and methotrexate (10-12.5 mg as a single dose per week). Remission was achieved in 24 patients after a median time of six months. The median follow-up of patients was five years (range 4 months-11 years). Five patients were lost to follow-up. Eight patients suffered a relapse. The mean time for relapse was 34 months after the initial remission. Seven out of eight patients remitted again after reinstitution of the initial induction regimen. One patient died of diffuse pulmonary haemorrhage despite early institution of therapy. CONCLUSION: WG is being increasingly diagnosed in India now because of greater awareness and diagnostic aids. Although remissions are easy to achieve, relapses continue to pose a challenge to the treating physician. | en_US |
dc.description.affiliation | Department of Medicine, All India Institute of Medical Sciences, New Delhi. ashok_145@hotmail.com | en_US |
dc.identifier.citation | Kumar A, Pandhi A, Menon A, Sharma SK, Pande JN, Malaviya AN. Wegener's granulomatosis in India: clinical features, treatment and outcome of twenty-five patients. The Indian Journal of Chest Diseases & Allied Sciences. 2001 Oct-Dec; 43(4): 197-204 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/29300 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://medind.nic.in/iae/iaem.shtml | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Glucocorticoids --administration & dosage | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | India | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Prednisolone --administration & dosage | en_US |
dc.subject.mesh | Retrospective Studies | en_US |
dc.subject.mesh | Wegener Granulomatosis --complications | en_US |
dc.title | Wegener's granulomatosis in India: clinical features, treatment and outcome of twenty-five patients. | en_US |
dc.type | Journal Article | en_US |
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