Unpacking VKC: How gender and age shape the clinical picture

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dc.contributor.authorChauhan, Gauraven_US
dc.contributor.authorMathimaaran, Suhitaen_US
dc.contributor.authorChandrasekar, Ambikaen_US
dc.contributor.authorChavda, Varsha Ben_US
dc.contributor.authorMugundhan, Ren_US
dc.contributor.authorSrinivasan, Bhaskaren_US
dc.contributor.authorIyer, Geethaen_US
dc.contributor.authorRajagopalan, Murlidharen_US
dc.contributor.authorAgarwal, Shwetaen_US
dc.date.accessioned2025-06-19T05:52:06Z
dc.date.available2025-06-19T05:52:06Z
dc.date.issued2025-04
dc.description.abstractPurpose: To investigate gender differences in childhood? and adult?onset vernal keratoconjunctivitis (VKC), as well as the variations between these onset groups. Methods: This was a retrospective, observational study (Jan 2015–Dec 2020). Electronic medical records of VKC patients managed by cornea specialists were analyzed based on their age of onset (<16 years for childhood [C?VKC], >16 years for adult [A?VKC]) and gender. Results: Out of 1018 VKC patients, 931 had childhood onset and 87 had adult onset. Both groups showed a male predominance; however, it was slightly less in A?VKC, with a mean follow?up of 28.6 ± 36.2 and 25.03 ± 40.3 months in C?VKC and A?VKC, respectively. A family history of allergies was observed only in C?VKC, with no gender differences. Asthma was more common in C?VKC, while skin allergies were more prevalent in A?VKC. Mixed VKC with Grade 4 severity was the most common in both age groups, with no gender differences in C?VKC; however, the limbal variant was more common in females with A?VKC. The proportion of A?VKC and C?VKC patients who developed complications was similar (P value 0.85). However, the C?VKC group had a significantly higher number of patients with multiple complications (P value 0.0076) as well as those requiring surgical intervention (P value 0.02). Keratoconus was the most common complication in both groups, but limbal stem cell deficiency was significantly higher in A?VKC across genders. Conclusion: Adult?onset VKC is a distinct condition with minor differences and a milder course compared to childhood?onset VKC. Notably, there are no significanten_US
dc.identifier.affiliationsCJ Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsCJ Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsElite School of Optometry, Unit of Medical Research Foundation, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsCJ Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsCJ Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsCJ Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsCJ Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsApollo Hospitals, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsCJ Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationChauhan Gaurav, Mathimaaran Suhita, Chandrasekar Ambika, Chavda Varsha B, Mugundhan R, Srinivasan Bhaskar, Iyer Geetha, Rajagopalan Murlidhar, Agarwal Shweta. Unpacking VKC: How gender and age shape the clinical picture. Indian Journal of Ophthalmology. 2025 Apr; 73(4): 594-598en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249882
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume73en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_177_25en_US
dc.subjectAdult?onset VKCen_US
dc.subjectsex hormonesen_US
dc.subjectvernal keratoconjunctivitisen_US
dc.titleUnpacking VKC: How gender and age shape the clinical pictureen_US
dc.typeJournal Articleen_US
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