Alterations in tumour suppressor gene p53 in human gliomas from Indian patients.

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dc.contributor.authorPhatak, Poornimaen_US
dc.contributor.authorSelvi, S Kalaien_US
dc.contributor.authorDivya, Ten_US
dc.contributor.authorHegde, A Sen_US
dc.contributor.authorHegde, Sridevien_US
dc.contributor.authorSomasundaram, Kumaravelen_US
dc.date.accessioned2002-12-07en_US
dc.date.accessioned2009-06-01T15:09:16Z
dc.date.available2002-12-07en_US
dc.date.available2009-06-01T15:09:16Z
dc.date.issued2002-12-07en_US
dc.description.abstractAlterations in tumour suppressor p53 gene are the most common defects seen in a variety of human cancers. In order to study the significance of the p53 gene in the genesis and development of human glioma from Indian patients, we checked 44 untreated primary gliomas for mutations in exons 5-9 of the p53 gene by PCR-SSCP and DNA sequencing. Sequencing analysis revealed six missense mutations. The incidence of p53 mutations was 13.6% (6 of 44). All the six mutations were found to be located in the central core domain of p53, which carries the sequence-specific DNA-binding domain. These results suggest a rather low incidence but a definite involvement of p53 mutations in the gliomas of Indian patients.en_US
dc.description.affiliationDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India.en_US
dc.identifier.citationPhatak P, Selvi SK, Divya T, Hegde AS, Hegde S, Somasundaram K. Alterations in tumour suppressor gene p53 in human gliomas from Indian patients. Journal of Biosciences. 2002 Dec; 27(7): 673-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111340
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBrain Neoplasms --geneticsen_US
dc.subject.meshExonsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, p53en_US
dc.subject.meshGlioma --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshMutation, Missenseen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_US
dc.subject.meshSequence Analysis, DNAen_US
dc.subject.meshTumor Suppressor Protein p53 --metabolismen_US
dc.titleAlterations in tumour suppressor gene p53 in human gliomas from Indian patients.en_US
dc.typeJournal Articleen_US
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