Does c-erbB-2 expression have a role in medulloblastoma prognosis?

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dc.contributor.authorBal, Munita Meenuen_US
dc.contributor.authorDas Radotra, Bishanen_US
dc.contributor.authorSrinivasan, Radhikaen_US
dc.contributor.authorSharma, Suresh Cen_US
dc.date.accessioned2006-10-23en_US
dc.date.accessioned2009-05-29T13:36:05Z
dc.date.available2006-10-23en_US
dc.date.available2009-05-29T13:36:05Z
dc.date.issued2006-10-23en_US
dc.description.abstractThe prognosis of patients with medulloblastoma has remained same for the last two decades. This study evaluated the role of c-erbB-2 expression in medulloblastoma as a prognostic marker. Fifty cases of medulloblastomas were investigated for the expression of c-erbB-2 protein using immunohistochemistry. The expression of c-erbB-2 was correlated with age, histology and disease-free survival (DFS). Thirty-five (70%) tumors were c-erbB-2 positive. Immunoreactivity for c-erbB-2 receptor was observed as mixed cytoplasmic and membrane positivity of tumour cells. The mean DFS in c-erbB-2 positive cases was 19.81 months compared to 48.33 months in c-erbB-2 negative cases. c-erbB-2 positivity was found to be an independent predictor of poor outcome in medulloblastoma (p value < 0.05). No correlation of c-erbB-2 expression was observed with the age of patient and the histological type of tumour. Additionally, c-erbB-4 expression was also evaluated in these tumours. Thirty-three cases showed co-expression of c-erbB-2 and c-erbB-4 proteins. However, c-erbB-4 expression alone was not associated with poor outcome, whereas its co-expression with c-erbB-2 was associated with shorter DFS (p < 0.05).en_US
dc.description.affiliationDepartment of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012.en_US
dc.identifier.citationBal MM, Das Radotra B, Srinivasan R, Sharma SC. Does c-erbB-2 expression have a role in medulloblastoma prognosis? Indian Journal of Pathology & Microbiology. 2006 Oct; 49(4): 535-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75823
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMedulloblastoma --diagnosisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrognosisen_US
dc.subject.meshReceptor, Epidermal Growth Factor --metabolismen_US
dc.subject.meshReceptor, erbB-2 --metabolismen_US
dc.titleDoes c-erbB-2 expression have a role in medulloblastoma prognosis?en_US
dc.typeJournal Articleen_US
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