Formulation design of Aceclofenac microcapsules by inotropic gelation technique, characterization studies and release kinetics.
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Date
2011-08
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Abstract
Osteoarthritis predominantly affects the large weight bearing joints and the clinical
characteristics include morning stiffness of short duration, stiffness or gelling on rest, pain on use,
joint inflammation and bone deformity. Microcapsules of aceclofenac were formulated with
methyl cellulose, sodium CMC and hydroxyl propyl methyl cellulose by technique. The
microcapsules showed excellent rheological properties for all batches. The formulations showed
drug content uniformity with high drug entrapment efficiency. The in vitro wash off test revealed
the mucoadhesive ability of the micro capsules. Scanning electron microscopy indicated structural
and surface morphology uniformity. The in vitro release studies indicated sustained release of
aceclofenac from the formulations. Kinetic study of the release data indicated the zero order
release and non fickian sustained release mode of drug release. The microcapsules showed the
correlation between wall thickness and drug release pattern.
Description
Keywords
Aceclofenac, Ionic gelation, Entrapment efficiency, In vitro release
Citation
Kumar A Ashok, Kumar Putta Rajesh, Kumar A Anil, Reddy K Lokeswara, Murthy T E G K, Rao T Venkateswara. Formulation design of Aceclofenac microcapsules by inotropic gelation technique, characterization studies and release kinetics. Journal of Applied Pharmaceutical Science. 2011 Aug; 1(6): 127-132.