Predisposing role of heterozygote MTHFR A1298C mutation in venous thrombosis in a pregnant patient: A case report.
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Date
2013-01
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Abstract
Congenital and acquired thrombophilia are associated with an increased risk of pregnancy-associated venous thrombosis (VT). Several genetic mechanisms have been investigated for their possible relationship with VT. Methyl tetrahydrofolate reductase gene polymorphisms are frequently in the MTHFR gene, which leads to a C to T change at position 677, has been suggested to alter the thrombohemostasis process and thrombophilia. Also, it has been found that MTHFR C1298C or MTHFR A1298C have no effect on the risk of VT. Herein, we describe deep VT (DVT) secondary to heterozygous MTHFR A1298C mutation in pregnant woman.
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Keywords
Pregnancy, MTHFR A1298C Mutation, Venous Thrombosis
Citation
Arduc Ayse, Isik Serhat, Dogan Berçem Aycicek,Ozuguz Ufuk, Akbaba Gulhan,Berker Dilek, Guler Serdar. Predisposing role of heterozygote MTHFR A1298C mutation in venous thrombosis in a pregnant patient: A case report. International Journal of Medical Science and Public Health. 2013 ; 2(1): 159-161.