Myoglobinuria: evaluation of methods in the clinical diagnosis acute renal failure.

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dc.contributor.authorAhsan, S Ken_US
dc.contributor.authorWashington, R Jen_US
dc.contributor.authorAhsan, Nen_US
dc.date.accessioned2001-08-25en_US
dc.date.accessioned2009-05-29T05:00:31Z
dc.date.available2001-08-25en_US
dc.date.available2009-05-29T05:00:31Z
dc.date.issued2001-08-25en_US
dc.description.abstractPatients with red--brown urine which may be a sign of myoglobinuria, can develop acute renal failure. We assayed serum creatinine, blood urea nitrogen (BUN) and creatine kinase activity in a total of 33 patients of equal groups, A (automobile accident), B (trauma) and C (undergoing rhabdomyolysis). In addition we tested 132 urine samples for the presence of myoglobin using a dipstick assay. Only five patients in group A showed any sign of myoglobinuria with increased creatine kinase activity upto 7 times the normal value but their serum creatinine level and BUN were within the normal range. In contrast, all 22 patients in group B and C showed myoglobinuria and above normal concentrations of serum creatinine and BUN, with significantly increased (p < 0.0001) creatine kinase activity upto 150 times the normal range. Four of the most seriously ill patients in group C developed acute renal failure. Supplementation of routine determinations of serum creatinine and BUN and serum creatine kinase activity with a rapid test for myoglobinuria provides an extra indication of impending renal dysfunction. It may be beneficial in the emergency management of these patients.en_US
dc.description.affiliationDepartment of Pathology, College of Medicine, King Faisal University, P.O. Box 2114, Dammam 31451, Saudi Arabia. skahsan@yahoo.comen_US
dc.identifier.citationAhsan SK, Washington RJ, Ahsan N. Myoglobinuria: evaluation of methods in the clinical diagnosis acute renal failure. Indian Journal of Medical Sciences. 2001 Aug; 55(8): 443-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/67145
dc.language.isoengen_US
dc.source.urihttps://www.indianjmedsci.orgen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Acute --diagnosisen_US
dc.subject.meshMyoglobinuria --complicationsen_US
dc.titleMyoglobinuria: evaluation of methods in the clinical diagnosis acute renal failure.en_US
dc.typeJournal Articleen_US
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