Myoglobinuria: evaluation of methods in the clinical diagnosis acute renal failure.
dc.contributor.author | Ahsan, S K | en_US |
dc.contributor.author | Washington, R J | en_US |
dc.contributor.author | Ahsan, N | en_US |
dc.date.accessioned | 2001-08-25 | en_US |
dc.date.accessioned | 2009-05-29T05:00:31Z | |
dc.date.available | 2001-08-25 | en_US |
dc.date.available | 2009-05-29T05:00:31Z | |
dc.date.issued | 2001-08-25 | en_US |
dc.description.abstract | Patients with red--brown urine which may be a sign of myoglobinuria, can develop acute renal failure. We assayed serum creatinine, blood urea nitrogen (BUN) and creatine kinase activity in a total of 33 patients of equal groups, A (automobile accident), B (trauma) and C (undergoing rhabdomyolysis). In addition we tested 132 urine samples for the presence of myoglobin using a dipstick assay. Only five patients in group A showed any sign of myoglobinuria with increased creatine kinase activity upto 7 times the normal value but their serum creatinine level and BUN were within the normal range. In contrast, all 22 patients in group B and C showed myoglobinuria and above normal concentrations of serum creatinine and BUN, with significantly increased (p < 0.0001) creatine kinase activity upto 150 times the normal range. Four of the most seriously ill patients in group C developed acute renal failure. Supplementation of routine determinations of serum creatinine and BUN and serum creatine kinase activity with a rapid test for myoglobinuria provides an extra indication of impending renal dysfunction. It may be beneficial in the emergency management of these patients. | en_US |
dc.description.affiliation | Department of Pathology, College of Medicine, King Faisal University, P.O. Box 2114, Dammam 31451, Saudi Arabia. skahsan@yahoo.com | en_US |
dc.identifier.citation | Ahsan SK, Washington RJ, Ahsan N. Myoglobinuria: evaluation of methods in the clinical diagnosis acute renal failure. Indian Journal of Medical Sciences. 2001 Aug; 55(8): 443-52 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/67145 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.indianjmedsci.org | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Kidney Failure, Acute --diagnosis | en_US |
dc.subject.mesh | Myoglobinuria --complications | en_US |
dc.title | Myoglobinuria: evaluation of methods in the clinical diagnosis acute renal failure. | en_US |
dc.type | Journal Article | en_US |
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