Characteristics & outcomes of cancer patients with COVID-19: A multicentre retrospective study from India

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dc.contributor.authorKumar, Akashen_US
dc.contributor.authorBaghmar, Saphaltaen_US
dc.contributor.authorMehta, Prashanten_US
dc.contributor.authorTiwari, Priyaen_US
dc.contributor.authorKumar, Laliten_US
dc.contributor.authorBakhshi, Sameeren_US
dc.contributor.authorAgarwal, Amiten_US
dc.contributor.authorGupta, Ishaanen_US
dc.contributor.authorTrikha, Anjanen_US
dc.contributor.authorBhatnagar, Sushmaen_US
dc.contributor.authorGogia, Ajayen_US
dc.contributor.authorMalik, Prabhat Singhen_US
dc.contributor.authorSahoo, Ranjit Kumaren_US
dc.contributor.authorRastogi, Sameeren_US
dc.contributor.authorPramanik, Rajaen_US
dc.contributor.authorBatra, Atulen_US
dc.contributor.authorPushpam, Deepamen_US
dc.contributor.authorSharma, Chitresh Ken_US
dc.contributor.authorSharma, Vinoden_US
dc.contributor.authorKataria, Babitaen_US
dc.contributor.authorGoyal, Kapilen_US
dc.contributor.authorSamaga, Shreyasen_US
dc.contributor.authorBothra, Sneha Jen_US
dc.contributor.authorSharma, Atulen_US
dc.date.accessioned2023-08-19T04:52:11Z
dc.date.available2023-08-19T04:52:11Z
dc.date.issued2022-06
dc.description.abstractBackground & objectives: High mortality has been observed in the cancer population affected with COVID-19 during this pandemic. We undertook this study to determine the characteristics and outcomes of cancer patients with COVID-19 and assessed the factors predicting outcome. Methods: Patients of all age groups with a proven history of malignancy and a recent diagnosis of SARS-CoV-2 infection based on nasal/nasopharyngeal reverse transcriptase (RT)-PCR tests were included. Demographic, clinical and laboratory variables were compared between survivors and non-survivors groups, with respect to observed mortality. Results: Between May 11 and August 10, 2020, 134 patients were included from the three centres and observed mortality was 17.1 per cent. The median age was 53 yr (interquartile range 39-61 yr) and thirty four patients (25%) were asymptomatic. Solid tumours accounted for 69.1 per cent and breast cancer was the most common tumour type (20%). One hundred and five patients (70.5%) had received chemotherapy within the past four weeks and 25 patients (19.3%) had neutropenia at presentation. On multivariate analysis, age [odds ratio (OR) 7.99 (95% confidence interval [CI] 1.18-54.00); P=0.033], haemoglobin [OR 6.28 (95% CI 1.07-37.04); P=0.042] neutrophil–lymphocyte ratio [OR 12.02 (95% CI 2.08-69.51); P=0.005] and baseline serum albumin [OR 18.52 (95% CI 2.80-122.27); P=0.002], were associated with higher mortality. Recent chemotherapy, haematological tumours type and baseline neutropenia did not affect the outcome. Interpretation & conclusions: Higher mortality in moderate and severe infections was associated with baseline organ dysfunction and elderly age. Significant proportion of patients were asymptomatic and might remain undetecteden_US
dc.identifier.affiliationsDepartments ofen_US
dc.identifier.affiliationsMedical Oncologyen_US
dc.identifier.affiliationsSurgical Oncology, National Cancer Institute, Departments ofen_US
dc.identifier.affiliationsMedical Oncologyen_US
dc.identifier.affiliationsOnco-Anaesthesia & Palliative Medicine, Dr B.R. Ambedkar Institute Rotary Cancer Hospitalen_US
dc.identifier.affiliationsDepartment of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciencesen_US
dc.identifier.affiliationsDepartment of Medical Oncology, BL Kapur Hospitalen_US
dc.identifier.affiliationsDepartment of Biochemical Engineering & Biotechnology, Institute of Technology, New Delhien_US
dc.identifier.affiliationsDepartment of Medical Oncology/Hematology/BMT, Asian Institute of Medical Sciencesen_US
dc.identifier.affiliationsDepartment of Medical Oncology, Artemis Hospital, Gurugram, Haryana, Indiaen_US
dc.identifier.citationKumar Akash, Baghmar Saphalta, Mehta Prashant, Tiwari Priya, Kumar Lalit, Bakhshi Sameer, Agarwal Amit, Gupta Ishaan, Trikha Anjan, Bhatnagar Sushma, Gogia Ajay, Malik Prabhat Singh, Sahoo Ranjit Kumar, Rastogi Sameer, Pramanik Raja, Batra Atul, Pushpam Deepam, Sharma Chitresh K, Sharma Vinod, Kataria Babita, Goyal Kapil, Samaga Shreyas, Bothra Sneha J, Sharma Atul. Characteristics & outcomes of cancer patients with COVID-19: A multicentre retrospective study from India. Indian Journal of Medical Research. 2022 Jun; 155(5-6): 546–553en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223627
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber5-6en_US
dc.relation.volume155en_US
dc.source.urihttps://doi.org/10.4103/ijmr.ijmr_1703_21en_US
dc.subjectCanceren_US
dc.subjectCOVID-19en_US
dc.subjectinfectionen_US
dc.subjectmortalityen_US
dc.subjectoutcomeen_US
dc.titleCharacteristics & outcomes of cancer patients with COVID-19: A multicentre retrospective study from Indiaen_US
dc.typeJournal Articleen_US
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