Primary endobronchial synovial sarcoma confirmed by SYT-SSX1 fusion gene transcript by reverse transcriptase polymerase chain reaction.

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dc.contributor.authorKumar, Rajiv
dc.contributor.authorMenon, Santosh
dc.contributor.authorDesai, Sangeeta B
dc.contributor.authorPramesh, C S
dc.contributor.authorMenon, Hari
dc.contributor.authorJambhekar, Nirmala Ajit
dc.date.accessioned2012-09-20T05:10:12Z
dc.date.available2012-09-20T05:10:12Z
dc.date.issued2009-10
dc.description.abstractPrimary sarcomas of lung are rare compared to metastatic sarcomas. Herein, we report a rare case of primary pulmonary synovial sarcoma with polypoid endobronchial growth in a 35-year-old lady who presented with cough and dyspnea. A malignant pulmonary tumor was suspected and left pneumonectomy was performed. Grossly, a non-encapsulated polypoidal endobronchial tumor measuring 6 cm in greatest diameter, with a solid, tan-white cut surface was identified. Microscopically, tumor was characterized by a proliferation of oval to spindle-shaped cells arranged in sheets and fascicles. Focal hemangiopericytomatous pattern was noted. Immunohistochemically, tumor cells were positive for vimentin, BCL-2, MIC-2 and calponin and focally positive for pancytokeratin and epithelial membrane antigen. A subsequent molecular analysis performed using reverse transcriptase-polymerase chain reaction with RNA extracted from paraffin-embedded tissue, revealed SYT/SSX1 fusion gene which confirmed the diagnosis of synovial sarcoma. The utility of immunohistochemistry and molecular techniques in diagnosis of such a rare case is stressed and the relevant literature is discussed.en_US
dc.identifier.citationKumar Rajiv, Menon Santosh, Desai Sangeeta B, Pramesh C S, Menon Hari, Jambhekar Nirmala Ajit. Primary endobronchial synovial sarcoma confirmed by SYT-SSX1 fusion gene transcript by reverse transcriptase polymerase chain reaction. Indian Journal of Pathology & Microbiology. 2009 Oct-Dec; 52(4): 520-523.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/141540
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=4;spage=520;epage=523;aulast=Kumaren_US
dc.subjectEndobronchial growthen_US
dc.subjectprimary pulmonary synovial sarcomaen_US
dc.subjectSYT-SSX1en_US
dc.titlePrimary endobronchial synovial sarcoma confirmed by SYT-SSX1 fusion gene transcript by reverse transcriptase polymerase chain reaction.en_US
dc.typeArticleen_US
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