A new membrane probing steroidal spin label: synthesis and applications.

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dc.contributor.authorKatoch, Ren_US
dc.contributor.authorTrivedi, G Ken_US
dc.contributor.authorPhadke, R Sen_US
dc.date.accessioned2000-02-13en_US
dc.date.accessioned2009-05-27T09:33:09Z
dc.date.available2000-02-13en_US
dc.date.available2009-05-27T09:33:09Z
dc.date.issued2000-02-13en_US
dc.description.abstractThe applicability of a new steroidal spin label, 3-oxo-androstan-17 beta-yl-(2",2",6",6"-tetramethyl-N-oxyl) piperidyl butan-1',4'-dioate, in studying the phase transition properties of model membrane L-alpha-dipalmitoyl phosphatidyl choline (DPPC) in the presence and absence of drugs has been explored. Its synthesis and characterization has been described herein. Besides, the localization of this spin label in lipid liposomes has been studied using electron spin resonance (ESR), differential scanning calorimetry (DSC) and 1H and 31P NMR spectroscopic techniques. The label has also been used to study the permeability of epinephrine into membrane. The results show that the spin label has a good potential as a spin probe in the study of biomembranes.en_US
dc.description.affiliationDepartment of Chemistry, Indian Institute of Technology, Mumbai, India.en_US
dc.identifier.citationKatoch R, Trivedi GK, Phadke RS. A new membrane probing steroidal spin label: synthesis and applications. Indian Journal of Biochemistry & Biophysics. 2000 Feb; 37(1): 45-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27850
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.mesh1,2-Dipalmitoylphosphatidylcholine --chemistryen_US
dc.subject.meshAndrostanes --chemical synthesisen_US
dc.subject.meshElectron Spin Resonance Spectroscopyen_US
dc.subject.meshLipid Bilayers --chemistryen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshSpin Labels --chemical synthesisen_US
dc.titleA new membrane probing steroidal spin label: synthesis and applications.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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