Correlation of the severity of atopic dermatitis with absolute eosinophil counts in peripheral blood and serum IgE levels.

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dc.contributor.authorDhar, Sandipanen_US
dc.contributor.authorMalakar, Rajiben_US
dc.contributor.authorChattopadhyay, Soumenen_US
dc.contributor.authorDhar, Subhraen_US
dc.contributor.authorBanerjee, Raghubiren_US
dc.contributor.authorGhosh, Apurbaen_US
dc.date.accessioned2009-05-28T08:27:21Z
dc.date.available2009-05-28T08:27:21Z
dc.date.issued2005-07-06en_US
dc.description.abstractBACKGROUND: Although a number of epidemiological studies, showing incidence and prevalence of atopic dermatitis, were available, scant attention has been paid to the correlation between the parameters of the disease like severity, absolute eosinophil count and IgE level, which has been known to be associated inconsistently. Hence this study was undertaken. METHODS: A total of 102 patients of atopic dermatitis, both children and adults, and 107 age matched controls were studied at the Pediatric Dermatology clinic, Institute of Child Health and department of Dermatology, AMRI-Apollo hospitals, Kolkata. RESULTS: The average age of onset of atopic dermatitis was observed to be 4.55 years. Both the average absolute eosinophil count and IgE levels in patients of atopic dermatitis were significantly higher than that of the controls. Each of these parameters showed significant correlation with severity of the disease and showed a nonhomogeneous distribution reflected by significant association with personal history of bronchial asthma and family history of atopy, when both parents were atopic. CONCLUSIONS: Our study shows that clinical activity of the disease as recorded by the "SCORAD" index can be used as an indicator of the hematological abnormalities as well as to some extent as a prognostic indicator. Family history of atopy correlates with the hematological abnormalities only if both parents are involved and bronchial asthma is the only associated atopic condition which correlates with the parameters of the disease .en_US
dc.description.affiliationDepartments of Dermatology, Institute of Child Health, Kolkata, India. babyd@vsnl.neten_US
dc.identifier.citationDhar S, Malakar R, Chattopadhyay S, Dhar S, Banerjee R, Ghosh A. Correlation of the severity of atopic dermatitis with absolute eosinophil counts in peripheral blood and serum IgE levels. Indian Journal of Dermatology, Venereology and Leprology. 2005 Jul-Aug; 71(4): 246-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/52635
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDermatitis, Atopic --blooden_US
dc.subject.meshEosinophilsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin E --blooden_US
dc.subject.meshInfanten_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.titleCorrelation of the severity of atopic dermatitis with absolute eosinophil counts in peripheral blood and serum IgE levels.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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