Causes of death and poor survival prognostic factors in thai patients with systemic sclerosis.

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dc.contributor.authorRuangjutipopan, Sutaten_US
dc.contributor.authorKasitanon, Nuntanaen_US
dc.contributor.authorLouthrenoo, Worawiten_US
dc.contributor.authorSukitawut, Warapornen_US
dc.contributor.authorWichainun, Ramjaien_US
dc.date.accessioned2009-05-27T18:25:24Z
dc.date.available2009-05-27T18:25:24Z
dc.date.issued2002-11-28en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractCauses of death and poor prognostic factors for patients with systemic sclerosis (SSc) were studied in 222 cases. Their mean age at the onset and duration of disease was 48.9 +/- 12.0 years and 23.3 +/- 29.3 months, respectively. Fifty-three per cent were diffuse subtype. Patients with diffuse SSc had more digital pitting scars and more muscle, heart, lung, and esophageal involvement than those with limited subtypes (p < or = 0.02). One hundred and six patients were lost to follow-up. With a median follow-up duration of 25 months, 31 of the remaining 116 patients (26.7%) died. SSc related death occurred in 18 cases, in which the lung, heart and kidney (renal crisis) were the major causes. Infection contributed to the remaining 13 deaths. When compared with living patients, using a univariate analysis, factors associated with a reduced survival rate were age of > 45 years at the onset, diffuse skin thickness, and lung, gastrointestinal tract, heart, kidney and muscle involvement (p < or = 0.001). In the multivariate analysis, only age of > 45 years at onset and cardiac involvement remained poor prognostic factors (p = 0.04 and 0.001, respectively).en_US
dc.description.affiliationDivision of Rheumatology, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.en_US
dc.identifier.citationRuangjutipopan S, Kasitanon N, Louthrenoo W, Sukitawut W, Wichainun R. Causes of death and poor survival prognostic factors in thai patients with systemic sclerosis. Journal of the Medical Association of Thailand. 2002 Nov; 85(11): 1204-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39115
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshCause of Deathen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshProbabilityen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshRegistriesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshScleroderma, Localized --diagnosisen_US
dc.subject.meshScleroderma, Systemic --diagnosisen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleCauses of death and poor survival prognostic factors in thai patients with systemic sclerosis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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