Outcomes of GnRH Agonist and GnRH Antagonist Regimens for IVF in Women Aged up to 40.
| dc.contributor.author | Jordão, Érika Vieira de Souza | |
| dc.contributor.author | Nakagawa, Hitomi Miura | |
| dc.contributor.author | Estrela, Flavielly Souza | |
| dc.contributor.author | Morais, Raiene Barbosa de | |
| dc.contributor.author | Gomes-Sobrinho, David Barreira | |
| dc.contributor.author | Carvalho, Bruno Ramalho de | |
| dc.date.accessioned | 2016-10-04T07:18:49Z | |
| dc.date.available | 2016-10-04T07:18:49Z | |
| dc.date.issued | 2016-01 | |
| dc.description.abstract | Objective: To compare outcomes among good-prognosis patients undergoing in vitro fertilization and intracytoplasmic sperm injection followed by embryo transfer (IVF/ ICSI-ET) in GnRH-agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) regimens. Methods: Retrospective analysis of 434 IVF/ICSI-ET cycles performed in a private center, in women aged up to 40: GnRH-a (n = 291) and GnRH-ant (n = 143). Pregestational, gestational and perinatal outcomes were evaluated. Statistical analysis was performed by unpaired t-test, Mann-Whitney test and Fisher’s exact test. Significance was set at p < 0.05. Results: GnRH-a regimen was associated with higher amounts of total oocytes (10.7 ± 5.7 vs 9.3 ± 5.7, p < 0.001), mature oocytes (8.2 ± 4,5 vs 6.8 ± 4.4, p < 0.001) and good quality embryos transferred (1.7 ± 0.8 vs 1.5 ± 0.9; p < 0.05). Rates of fertilization, embryo implantation and live births were also higher in GnRH-a (72.8%, 27.6% and 48.8%, respectively) compared to GnRH-ant (65.3%, 14.7% and 26.6%, respectively; p < 0.0001). There were no significant differences between rates of preterm delivery or low birth weight, comparing the two groups. Conclusion: Our results suggest that the long GnRH-a regimen is the one that offers the best reproductive outcomes among in women aged up to 40 undergoing IVF/ICSI-ET. | en_US |
| dc.identifier.citation | Jordão Érika Vieira de Souza, Nakagawa Hitomi Miura, Estrela Flavielly Souza, Morais Raiene Barbosa de, Gomes-Sobrinho David Barreira, Carvalho Bruno Ramalho de. Outcomes of GnRH Agonist and GnRH Antagonist Regimens for IVF in Women Aged up to 40. Acta Medica International. 2016 Jan-June; 3(1): 46-49. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/177570 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.actamedicainternational.com/article/28 | en_US |
| dc.subject | GnRH agonist | en_US |
| dc.subject | GnRH antagonist | en_US |
| dc.subject | IVF | en_US |
| dc.subject | ICSI | en_US |
| dc.subject | Reproductive outcomes | en_US |
| dc.title | Outcomes of GnRH Agonist and GnRH Antagonist Regimens for IVF in Women Aged up to 40. | en_US |
| dc.type | Article | en_US |