Sensitivity of different isolates of Schistosoma japonicum from China to praziquantel.

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dc.contributor.authorHe, Y Xen_US
dc.contributor.authorHu, Y Qen_US
dc.contributor.authorYu, Q Fen_US
dc.date.accessioned2009-05-27T15:09:37Z
dc.date.available2009-05-27T15:09:37Z
dc.date.issued1992-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractGroups of C57BL inbred mice infected with each of the 4 different isolates, (Anhui, Hubei, Sichuan and Yunnan) of Schistosoma japonicum from the mainland of China were treated with praziquantel (PZQ) and the parasiticidal effects were compared. Worm reduction rate was recorded to assess systematically the sensitivity of 4 different isolates to PZQ in the mouse. Three dosage-levels of PZQ, ie 150, 230 and 310 mg/kg body weight in single doses were used. The worm development rates of control groups infected with schistosomes from Anhui, Hubei, Sichuan and Yunnan were 75.5, 81.8, 81.5, and 83.0%, respectively. At the dosage-level of 150 mg/kg, the worm reduction rates for the 4 different isolates were 36.0, 33.9, 25.5 and 35.6%, respectively. At the dosage-level of 230 mg/kg, the rates were 47.1, 46.0, 38.1 and 47.7%, while at the dosage-level of 310 mg/kg, they were 59.3, 58.6, 50.8 and 61.7%, respectively. The results indicated that the worm reduction rate of the Sichuan isolate was lower than that of the other three isolates, however, the differences were not statistically significant, suggesting that schistosomes of Anhui, Hubei, Sichuan and Yunnan isolates bear resemblance in drug response.en_US
dc.description.affiliationChinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China.en_US
dc.identifier.citationHe YX, Hu YQ, Yu QF. Sensitivity of different isolates of Schistosoma japonicum from China to praziquantel. The Southeast Asian Journal of Tropical Medicine and Public Health. 1992 Jun; 23(2): 261-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32069
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChinaen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshPraziquantel --administration & dosageen_US
dc.subject.meshSchistosoma japonicum --drug effectsen_US
dc.subject.meshSchistosomiasis japonica --drug therapyen_US
dc.subject.meshSnailsen_US
dc.titleSensitivity of different isolates of Schistosoma japonicum from China to praziquantel.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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