Role of circulating microRNAs in non-small cell lung carcinoma

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dc.contributor.authorBaranwal, Harshitaen_US
dc.contributor.authorMishra, Shravan K.en_US
dc.contributor.authorKumari, Nirajen_US
dc.contributor.authorSingh, Shalinien_US
dc.contributor.authorKrishnani, Narendraen_US
dc.contributor.authorNath, Aloken_US
dc.contributor.authorNeyaz, Zafaren_US
dc.date.accessioned2025-05-09T09:57:05Z
dc.date.available2025-05-09T09:57:05Z
dc.date.issued2024-09
dc.description.abstractIntroduction: Non?small cell lung cancer (NSCLC) is the leading cause of mortality globally. Early imaging detection modalities are associated with high false?positive rates and radiation exposure. A non?invasive biomarker can serve as an improvised method for early detection. MicroRNAs can serve as a potential non?invasive biomarker as they are stable in circulation, tissue or biological process?specific, easy to detect, cost?effective, and not associated with radiation hazards. This study validates circulating microRNA in NSCLC of the Indian population and studies its correlation with clinicopathological parameters. Materials and Methods: Circulating microRNA (?miR?193b, miR?301a, miR?7, and miR?25) was evaluated in 101 cases of tissue?proven NSCLC and 28 controls in serum samples. Results: There were 67 male and 34 female patients (Male: Female = 1.97:1). The age range was 25 to 86 years with a median age of 60 years. There was a significant upregulation in the expression of miR?193b in the NSCLC group as compared to controls (P = 0.034). MiR?7 was also upregulated while miR?25 and miR?301a were downregulated in NSCLC as compared to controls; however, a level of significance was not achieved. ROC curve analysis for miR?193b showed an AUC of 0.636 (95% CI, 0.522?0.750; P-value = 0.036) between NSCLC cases and controls. Conclusion: The present study showed variable expression of the above?studied miRNAs. MiR?193b showed a significant upregulation in cancer patients; however, the other three miRNAs were not conclusive. This suggests that profiling of microRNA in each population is essential to search for a valid non?invasive biomarker in that population.en_US
dc.identifier.affiliationsDepartment of Pathology, Sanjay Gandhi Postgraduate Institutes of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Sanjay Gandhi Postgraduate Institutes of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, Sanjay Gandhi Postgraduate Institutes of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Sanjay Gandhi Postgraduate Institutes of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, Sanjay Gandhi Postgraduate Institutes of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Radiodiagnosis, Sanjay Gandhi Postgraduate Institutes of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationBaranwal Harshita, Mishra Shravan K., Kumari Niraj, Singh Shalini, Krishnani Narendra, Nath Alok, Neyaz Zafar. Role of circulating microRNAs in non-small cell lung carcinoma. Indian Journal of Pathology & Microbiology. 2024 Sep; 67(3): 502-509en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245474
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume67en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_849_22en_US
dc.subjectCirculating biomarkeren_US
dc.subjectmicroRNAen_US
dc.subjectnon?small?cell lung canceren_US
dc.subjectquantitative reverse transcription polymerase chain reactionen_US
dc.subjectserum microRNAsen_US
dc.titleRole of circulating microRNAs in non-small cell lung carcinomaen_US
dc.typeJournal Articleen_US
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