A factor in a wild isolated Neurospora crassa strain enables a chromosome segment duplication to suppress repeat-induced point mutation.

Simple item page
dc.contributor.authorRamakrishnan, Mukund
dc.contributor.authorSowjanya, T Naga
dc.contributor.authorRaj, Kranthi B
dc.contributor.authorKasbekar, Durgadas P
dc.date.accessioned2015-08-08T09:11:25Z
dc.date.available2015-08-08T09:11:25Z
dc.date.issued2011-12
dc.description.abstractRepeat-induced point mutation (RIP) is a sexual stage-specific mutational process of Neurospora crassa and other fungi that alters duplicated DNA sequences. Previous studies from our laboratory showed that chromosome segment duplications (Dps) longer than ~300 kbp can dominantly suppress RIP, presumably by titration of the RIP machinery, and that although Dps <200 kbp did not individually suppress RIP, they could do so in homozygous and multiply heterozygous crosses, provided the sum of the duplicated DNA exceeds ~300 kbp. Here we demonstrate suppression of RIP in a subset of progeny carrying the normally sub-threshold 154 kbp Dp(R2394) from a cross of T(R2394) to the wild isolated Carrefour Mme. Gras strain (CMG). Thus, the CMG strain contains a factor that together with Dp(R2394) produces a synthetic RIP suppressor phenotype. It is possible that the factor is a cryptic Dp that together with Dp(R2394) can exceed the size threshold for titration of the RIP machinery and thereby causes RIP suppression.en_US
dc.identifier.citationRamakrishnan Mukund, Sowjanya T Naga, Raj Kranthi B, Kasbekar Durgadas P. A factor in a wild isolated Neurospora crassa strain enables a chromosome segment duplication to suppress repeat-induced point mutation. Journal of Biosciences. 2011 Dec; 36 (5): 817-821.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/161615
dc.language.isoenen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/dec2011/817.pdfen_US
dc.subjectChromosome segment duplicationsen_US
dc.subjectdominant suppressor of RIPen_US
dc.subjectgenome defense in fungien_US
dc.titleA factor in a wild isolated Neurospora crassa strain enables a chromosome segment duplication to suppress repeat-induced point mutation.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jb2011v36n5p817.pdf
Size:
137.38 KB
Format:
Adobe Portable Document Format
Description:
Journal artical
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal of Biosciences