Kainic acid induced epileptogenesis in developing normal & undernourished rats--a computerised EEG analysis.

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dc.contributor.authorSharma, S Ken_US
dc.contributor.authorSelvamurthy, Wen_US
dc.contributor.authorMaheshwari, M Cen_US
dc.contributor.authorSingh, T Pen_US
dc.date.accessioned1990-12-01en_US
dc.date.accessioned2009-05-27T08:04:15Z
dc.date.available1990-12-01en_US
dc.date.available2009-05-27T08:04:15Z
dc.date.issued1990-12-01en_US
dc.description.abstractExperimental epilepsy was induced in developing normal, undernourished and subsequently rehabilitated rats by locally injecting graded doses of Kainic acid (KA) in the right frontal cortex. Frequency and power spectral analysis of EEG was carried out to assess the progressive changes in EEG during KA-epileptogenesis. Undernourished animals were highly susceptible to seizure discharge. They exhibited generalized tonic-clonic discharge and had episodes of clinical seizures even after temporary neuronal recovery. Increase in power of delta, theta and decrease in alpha power was observed in the compressed spectral array (CSA) of undernourished animals. Delayed neuronal recovery with reduced background EEG and marked electrosilence in response to intra-rectal sodium valproate was observed in undernourished animals. Rehabilitated animals exhibited partial recovery which was related to the body weight gain. Spike frequency, spike amplitude and neuronal recovery time were not significantly differet between normal and undernourished animals at lower doses of KA (7.5-60 ng) whereas at higher doses (120-500 ng) marked differences were observed in these parameters. In KA treated undernourished rats 3H-glycine incorporation was significantly higher than normal in the hippocampus and spinal cord and lower in the cerebellum.en_US
dc.description.affiliationDepartment of Neurology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSharma SK, Selvamurthy W, Maheshwari MC, Singh TP. Kainic acid induced epileptogenesis in developing normal & undernourished rats--a computerised EEG analysis. Indian Journal of Medical Research. 1990 Dec; 92(): 456-66en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23130
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCerebellum --metabolismen_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshGlycine --metabolismen_US
dc.subject.meshHippocampus --metabolismen_US
dc.subject.meshKainic Acid --antagonists & inhibitorsen_US
dc.subject.meshNutrition Disorders --complicationsen_US
dc.subject.meshRats --growth & developmenten_US
dc.subject.meshSeizures --chemically induceden_US
dc.subject.meshSpinal Cord --metabolismen_US
dc.subject.meshValproic Acid --pharmacologyen_US
dc.titleKainic acid induced epileptogenesis in developing normal & undernourished rats--a computerised EEG analysis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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