Hypolactasia as a molecular basis of lactose intolerance.

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dc.contributor.authorKaur, Kamaljiten_US
dc.contributor.authorMahmood, Safrunen_US
dc.contributor.authorMahmood, Akhtaren_US
dc.date.accessioned2006-10-01en_US
dc.date.accessioned2009-05-27T09:13:47Z
dc.date.available2006-10-01en_US
dc.date.available2009-05-27T09:13:47Z
dc.date.issued2006-10-01en_US
dc.description92 references.en_US
dc.description.abstractLactase-phlorizin hydrolase (LPH), a membrane-bound glycoprotein present in the luminal surface of enterocytes in the intestine is responsible for lactose intolerance, a phenomenon prevalent in humans worldwide. In the rodent intestine, the post-natal development of the LPH follows a specific pattern, such that the enzyme levels are high in the peri-natal period, but declines considerably upon maturation. The observed maturational decline in the LPH activity is very similar to adult-type hypolactasia observed in humans. Majority of the studies have been carried out using animal models or cell lines and a number of hypotheses have been put forward to explain the maturational decline of lactase activity such as: (a) decreased amount of lactase protein, (b) defect in post-translational modification of precursor lactase to the mature enzyme, and (c) synthesis of an inactive, high molecular weight lactase with altered glycosylation, however, the precise underlying mechanism of adult-type hypolactasia remains undefined. The present review describes the recent developments in understanding the regulation of lactase expression and the possible mechanism of adult-type hypolactasia, as a cause of lactose intolerance.en_US
dc.description.affiliationDepartment of Biochemistry, Panjab University, Chandigarh 160 014, India.en_US
dc.identifier.citationKaur K, Mahmood S, Mahmood A. Hypolactasia as a molecular basis of lactose intolerance. Indian Journal of Biochemistry & Biophysics. 2006 Oct; 43(5): 267-74en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26865
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGene Expression Regulation, Enzymologicen_US
dc.subject.meshGlycosylationen_US
dc.subject.meshGlycosylceramidase --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshLactase --biosynthesisen_US
dc.subject.meshLactose --geneticsen_US
dc.subject.meshLactose Intolerance --etiologyen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.titleHypolactasia as a molecular basis of lactose intolerance.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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