Hypolactasia as a molecular basis of lactose intolerance.
dc.contributor.author | Kaur, Kamaljit | en_US |
dc.contributor.author | Mahmood, Safrun | en_US |
dc.contributor.author | Mahmood, Akhtar | en_US |
dc.date.accessioned | 2006-10-01 | en_US |
dc.date.accessioned | 2009-05-27T09:13:47Z | |
dc.date.available | 2006-10-01 | en_US |
dc.date.available | 2009-05-27T09:13:47Z | |
dc.date.issued | 2006-10-01 | en_US |
dc.description | 92 references. | en_US |
dc.description.abstract | Lactase-phlorizin hydrolase (LPH), a membrane-bound glycoprotein present in the luminal surface of enterocytes in the intestine is responsible for lactose intolerance, a phenomenon prevalent in humans worldwide. In the rodent intestine, the post-natal development of the LPH follows a specific pattern, such that the enzyme levels are high in the peri-natal period, but declines considerably upon maturation. The observed maturational decline in the LPH activity is very similar to adult-type hypolactasia observed in humans. Majority of the studies have been carried out using animal models or cell lines and a number of hypotheses have been put forward to explain the maturational decline of lactase activity such as: (a) decreased amount of lactase protein, (b) defect in post-translational modification of precursor lactase to the mature enzyme, and (c) synthesis of an inactive, high molecular weight lactase with altered glycosylation, however, the precise underlying mechanism of adult-type hypolactasia remains undefined. The present review describes the recent developments in understanding the regulation of lactase expression and the possible mechanism of adult-type hypolactasia, as a cause of lactose intolerance. | en_US |
dc.description.affiliation | Department of Biochemistry, Panjab University, Chandigarh 160 014, India. | en_US |
dc.identifier.citation | Kaur K, Mahmood S, Mahmood A. Hypolactasia as a molecular basis of lactose intolerance. Indian Journal of Biochemistry & Biophysics. 2006 Oct; 43(5): 267-74 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/26865 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.asp | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Gene Expression Regulation, Enzymologic | en_US |
dc.subject.mesh | Glycosylation | en_US |
dc.subject.mesh | Glycosylceramidase --chemistry | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lactase --biosynthesis | en_US |
dc.subject.mesh | Lactose --genetics | en_US |
dc.subject.mesh | Lactose Intolerance --etiology | en_US |
dc.subject.mesh | Polymorphism, Genetic | en_US |
dc.title | Hypolactasia as a molecular basis of lactose intolerance. | en_US |
dc.type | Journal Article | en_US |
dc.type | Research Support, Non-U.S. Gov't | en_US |
dc.type | Review | en_US |
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