Antioxidant and tyrosinase inhibitory activity of face serum containing cocoa pod husk phytosome (Theobroma cacao L.)

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dc.contributor.authorSani, Ega Prianien_US
dc.contributor.authorSaskara, Apriliaen_US
dc.contributor.authorRatih, Aryanien_US
dc.contributor.authorLeni, Purwantien_US
dc.date.accessioned2020-10-16T08:55:46Z
dc.date.available2020-10-16T08:55:46Z
dc.date.issued2019-10
dc.description.abstractHigh polyphenol content of cocoa pod extract causing it potential to be developed as antioxidant and tyrosinaseinhibitory agent in cosmetic preparations. Phytosome system known could enhance skin penetration of phytoconstituentlike polyphenol-rich extract. The objectives of this research were to formulate phytosome containing cocoa podextract, develop phytosome complex into face serum preparation, and determine antioxidant and tyrosinase inhibitoryactivities of the extract and the formulated serum. The cocoa pod extract was developed into phytosome system bythin-layer method using soy-phosphatidylcholine. The phytosome then develop into face serum formulation usingViscolam MAC 10 as a gelling agent. The antioxidant activity was conducted by 2,2-diphenyl-1-picrylhydrazyl radicalscavenging assay and tyrosinase inhibitory activity was conducted by colorimetric enzymatic assay. The cocoa podextract has very strong antioxidant activity with inhibitory concentration (IC50) of 17.21 ppm. The extract also hastyrosinase inhibitory activity with IC50 of 199.98 ppm. The phytosome complex containing cocoa pod extract andphosphatidylcholine (1:1) has good entrapment efficiency (90.5%) with an average particle size of 672 nm. Theformulated face serum has good physical characteristic and also has antioxidant and tyrosinase inhibitory activitiesthat equal with the marketed product (Hadalabo ultimate whitening milk, Rohto, Indonesia).en_US
dc.identifier.affiliationsPharmacy Department, UNISBA, Bandung, West Java, Indonesia.en_US
dc.identifier.citationSani Ega Priani, Saskara Aprilia, Ratih Aryani, Leni Purwanti. Antioxidant and tyrosinase inhibitory activity of face serum containing cocoa pod husk phytosome (Theobroma cacao L.). Journal of Applied Pharmaceutical Science. 2019 Oct; 2019 Oct: 110-115en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210471
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber10en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.91015en_US
dc.subjectCocoa pod husken_US
dc.subjectphytosomeen_US
dc.subjectserumen_US
dc.subjectinhibitor tyrosinaseen_US
dc.subjectantioxidant.en_US
dc.titleAntioxidant and tyrosinase inhibitory activity of face serum containing cocoa pod husk phytosome (Theobroma cacao L.)en_US
dc.typeJournal Articleen_US
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