The pattern of hypogammaglobulinaemia in Sri Lankan children.

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dc.contributor.authorde Silva, N Ren_US
dc.contributor.authorGunawardena, Sen_US
dc.contributor.authorRatnayake, Hen_US
dc.contributor.authorWeerasinghe, Aen_US
dc.date.accessioned2009-05-28T05:47:44Z
dc.date.available2009-05-28T05:47:44Z
dc.date.issued2000-06-29en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractOBJECTIVE: To evaluate the prevalence of hypogammaglobulinaemia in Sri Lankan children who present with recurrent or severe bacterial infections. DESIGN: A descriptive study. SETTING: Medical Research Institute (MRI), Colombo. SUBJECTS: 100 children between the ages of four months to twelve years referred to the Department of Immunology, MRI, for evaluation of immune status during four years from 1993 to 1997. MEASUREMENTS: Immunoglobulin G, A and M levels were measured using radial immunodiffusion technique. RESULTS: 22 out of 100 children had an underlying antibody deficiency, of whom IgA deficiency was the commonest (18 patients). Two patients had low IgG and A and elevated IgM levels, and they were diagnosed as having X linked-hyper-IgM syndrome. One patient had deficient IgA and IgM, and all three immunoglobulins were deficient in another. CONCLUSIONS: Results indicate that IgA deficiency is the commonest immunodeficiency in Sri Lanka, which is comparable with studies done in the West. This study also shows the need to improve the standard of care in patients with immunodeficiency.en_US
dc.description.affiliationDepartment of Immunology, Medical Research Institute, Colombo.en_US
dc.identifier.citationde Silva NR, Gunawardena S, Ratnayake H, Weerasinghe A. The pattern of hypogammaglobulinaemia in Sri Lankan children. The Ceylon Medical Journal. 2000 Jun; 45(2): 58-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/49049
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.subject.meshAgammaglobulinemia --complicationsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCommunicable Diseases --etiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunocompromised Hosten_US
dc.subject.meshImmunoglobulin A --blooden_US
dc.subject.meshImmunoglobulin G --blooden_US
dc.subject.meshImmunoglobulin M --blooden_US
dc.subject.meshInfanten_US
dc.subject.meshPrevalenceen_US
dc.subject.meshSri Lanka --epidemiologyen_US
dc.titleThe pattern of hypogammaglobulinaemia in Sri Lankan children.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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