Prenatal sonographic diagnosis of holoprosencephaly.

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dc.contributor.authorTongsong, Ten_US
dc.contributor.authorWanapirak, Cen_US
dc.contributor.authorSirichotiyakul, Sen_US
dc.contributor.authorSiriangkul, Sen_US
dc.date.accessioned2009-05-27T19:57:34Z
dc.date.available2009-05-27T19:57:34Z
dc.date.issued1998-03-12en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThe purpose of this series was to describe the sonographic features of fetal holoprosencephaly prenatally. The study was undertaken at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai University. A total of 12 fetuses with prenatal diagnosis of holoprosencephaly were sonographically evaluated and followed-up. The study revealed that all showed monoventricular cavity, fused thalami, no falx and cavum septum pellucidum. Eight of them were correctly diagnosed sonographically in the first two trimesters. Extrafacial anomalies were also identified in half of the fetuses and all of them had facial abnormalities. Twenty-five per cent (3 cases) had polyhydramnios and only one case had oligohydramnios. Chromosome study revealed that 70 per cent had normal chromosomes, 30 per cent were aneuploidy, trisomy 13; 2 cases and trisomy 18; 1 case. In conclusion, this series indicates that ultrasound has a high predictive value in the diagnosis of holoprosencephaly. The most valuable clue to the diagnosis is the demonstration of the single ventricle. Additionally, demonstration of facial abnormalities may add confidence to the diagnosis. Conversely, should any of these facial features be serendipitously encountered, a careful examination of the intracranial contents is recommended.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.en_US
dc.identifier.citationTongsong T, Wanapirak C, Sirichotiyakul S, Siriangkul S. Prenatal sonographic diagnosis of holoprosencephaly. Journal of the Medical Association of Thailand. 1998 Mar; 81(3): 208-13en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/42112
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHoloprosencephaly --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshParityen_US
dc.subject.meshPregnancyen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.titlePrenatal sonographic diagnosis of holoprosencephaly.en_US
dc.typeJournal Articleen_US
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