Your dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia.

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dc.contributor.authorGupta, Anurag
dc.contributor.authorGoyal, Manu
dc.contributor.authorNidamanuri, Koteswara Rao
dc.contributor.authorDattatreya, Palanki Satya
dc.date.accessioned2015-02-12T04:56:21Z
dc.date.available2015-02-12T04:56:21Z
dc.date.issued2014-01
dc.description.abstractB-cell acute lymphoblastic leukemia (B-ALL) is characterized by CD19 expression, which is one of the most important prerequisites, along with expression of CD10, CD22 and/or CD79a. Rearrangements involving MLL gene are seen in CD10− B-ALL (pro-B cell origin) and t(9;11)(p21;q23) is most commonly reported in acute myeloid leukemia (AML), where it is known to carry very good prognosis in pediatric AMLs and rarely in acute lymphoblastic leukemia (ALL). We report a case of CD10+, CD19− pediatric ALL with rearrangements of MLL gene as a result of t(9;11)(p21;q23), thus conferring a very poor prognosis. The case emphasizes use of comprehensive panel of antibodies for fl ow cytometric immunophenotyping and cytogenetic correlation for correct diagnosis and prognostication. KEY WORDS: Acute lymphoblastic leukemia, CD19, MLL gene, t(9;11)(p21;q23)en_US
dc.identifier.citationGupta Anurag, Goyal Manu, Nidamanuri Koteswara Rao, Dattatreya Palanki Satya. Your dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia. Indian Journal of Pathology & Microbiology. 2014 Jan-Mar 57 (1): 78-80.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155973
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=1;spage=78;epage=80;aulast=Guptaen_US
dc.subjectAcute lymphoblastic leukemiaen_US
dc.subjectCD19en_US
dc.subjectMLL geneen_US
dc.subjectt(9;11)(p21;q23)en_US
dc.titleYour dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia.en_US
dc.typeArticleen_US
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