Radiotherapy for stage I seminoma of the testis.

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dc.contributor.authorYoney, A
dc.contributor.authorYildirim, C
dc.contributor.authorIsikli, L
dc.contributor.authorAkboru, H
dc.contributor.authorUnsal, M
dc.date.accessioned2013-01-15T06:04:35Z
dc.date.available2013-01-15T06:04:35Z
dc.date.issued2010-04
dc.description.abstractBackground : After orchiectomy in stage I seminoma the standard is adjuvant radiation therapy. We analyzed the patients retrospectively to evaluate the contributions of the treatment volume and dosage to treatment outcomes. Materials and Methods : Between January 1999 and December 2005, 91 stage I seminoma patients with a median age 36 (range;22-62) applied to our center, who were treated using anterior-posterior parallel opposed fields with linear accelerator or Co60 after orchiectomy. Twenty-five (27.5%) patients received irradiation to the paraaortic and ipsilateral pelvic nodes, and 66 (62.5%) patients only received to paraaortic nodes. Results : With a follow up time of median 57 months (range; 27-104), paraaortic nodes treated group had 4 relapses (6%) - 3 of them pelvic, one of them both pelvic and paraaortic. Both paraaortic and ipsilateral nodes irradiated patients had only one relapse (4%) (P = 0.726). While the 5 year overall survival (OS) is 98.8%, it is 100% in the dog-leg group and 98.4% in the paraaortic group (P = 0.548). Univariate analyses of OS and Disease Free Survival (DFS) showed that there is no statistically significant difference related to factors as age, histologic subgroup, tumor size, rete testis involvement, radiotherapy (RT) fields, dose ranges and the therapy device. Conclusion : Adjuvant RT approach is the preferred for non-compliant low risk patients as well as intermediate and high risk patient in stage I seminoma. 20 Gy/ 10 fractions/ 2 weeks RT is the adequate treatment.en_US
dc.identifier.citationYoney A, Yildirim C, Isikli L, Akboru H, Unsal M. Radiotherapy for stage I seminoma of the testis. Indian Journal of Cancer. 2010 Apr-June; 47(2): 179-183.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144326
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2010;volume=47;issue=2;spage=179;epage=183;aulast=Yoneyen_US
dc.subjectStage I seminomaen_US
dc.subjectrisk-adapted therapyen_US
dc.subjectradiotherapyen_US
dc.subjectparaaortic fielden_US
dc.subjectdog-leg fielden_US
dc.subject.meshAdult
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshRadiotherapy, Adjuvant
dc.subject.meshRetrospective Studies
dc.subject.meshSeminoma --pathology
dc.subject.meshSeminoma --radiotherapy
dc.subject.meshTesticular Neoplasms --pathology
dc.subject.meshTesticular Neoplasms --radiotherapy
dc.subject.meshYoung Adult
dc.titleRadiotherapy for stage I seminoma of the testis.en_US
dc.typeArticleen_US
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