Melatonin treatment prevents modulation of cell-mediated immune response induced by propoxur in rats.

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dc.contributor.authorSuke, Sanvidhan Gen_US
dc.contributor.authorPathak, Rahulen_US
dc.contributor.authorAhmed, Rafat Sen_US
dc.contributor.authorTripathi, A Ken_US
dc.contributor.authorBanerjee, B Den_US
dc.date.accessioned2008-08-16en_US
dc.date.accessioned2009-05-27T09:36:38Z
dc.date.available2008-08-16en_US
dc.date.available2009-05-27T09:36:38Z
dc.date.issued2008-08-16en_US
dc.description.abstractThe effect of melatonin, a major secretory product of the pineal gland, in attenuation of propoxur (2-isopropoxy phenyl N-methyl carbamate)-induced modulation of cell-mediated immune (CMI) response was studied in rats. Male Wistar albino rats were exposed to propoxur (a widely used pesticide) orally (10 mg/kg) and/or melatonin (10 mg/kg) orally for 4 weeks. CMI was measured by delayed-type hypersensitivity (DTH), leucocyte and macrophage migration inhibition (LMI and MMI) responses and estimation of cytokines TNF-alpha and IFN-gamma levels. Rats exposed to propoxur for 4 weeks showed significant decrease in DTH, LMI and MMI responses. Propoxur also suppressed TNF-alpha and IFN-gamma production significantly. Administration of melatonin alone caused a significant increase in DTH response. Although there were no changes in the LMI and MMI response, the cytokine levels were significantly increased, as compared to control. Co-administration of melatonin along with propoxur significantly nullified the effect of the pesticide on the CMI response, except DTH and reversed levels of cytokines to near control/normal values. Thus, melatonin treatment considerably attenuated immunomodulation caused by sub-chronic treatment of propoxur in experimental animals.en_US
dc.description.affiliationEnvironmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences and G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110 095, India.en_US
dc.identifier.citationSuke SG, Pathak R, Ahmed RS, Tripathi AK, Banerjee BD. Melatonin treatment prevents modulation of cell-mediated immune response induced by propoxur in rats. Indian Journal of Biochemistry & Biophysics. 2008 Aug; 45(4): 278-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28025
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --administration & dosageen_US
dc.subject.meshCytokines --immunologyen_US
dc.subject.meshHypersensitivity, Delayed --immunologyen_US
dc.subject.meshImmunity, Cellular --drug effectsen_US
dc.subject.meshLeukocytes --drug effectsen_US
dc.subject.meshMacrophages --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin --administration & dosageen_US
dc.subject.meshPesticides --antagonists & inhibitorsen_US
dc.subject.meshPineal Gland --chemistryen_US
dc.subject.meshPropoxur --antagonists & inhibitorsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTumor Necrosis Factor-alpha --immunologyen_US
dc.titleMelatonin treatment prevents modulation of cell-mediated immune response induced by propoxur in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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