Analysis of clinicopathological and immunohistochemical parameters and correlation of outcomes in gastrointestinal stromal tumors

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dc.contributor.authorVarshney, Vaibhav Kumaren_US
dc.contributor.authorGupta, Rakesh Kumaren_US
dc.contributor.authorSaluja, Sundeep Singhen_US
dc.contributor.authorTyagi, Ilaen_US
dc.contributor.authorMishra, Pramod Kumaren_US
dc.contributor.authorBatra, Vineeta Ven_US
dc.date.accessioned2020-01-02T06:26:57Z
dc.date.available2020-01-02T06:26:57Z
dc.date.issued2019-04
dc.description.abstractINTRODUCTION: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We analyzed the clinicopathological features, resectability, immunohistochemical markers, and various factors predictive of disease recurrence and survival. MATERIALS AND METHODS: Retrospective analysis of prospectively maintained database of GIST patients managed from 2005 to 2016 was done. Size, site, malignant potential, nuclear pleomorphism, histopathological variety, immunohistochemical markers, type of surgery, and adjuvant imatinib therapy were analyzed. RESULTS: Ninety-two patients with GIST were analyzed. Immunohistochemistry showed positivity for c-kit (82.4%), DOG1 (75%), and PDGFR-α (79%). Among 16 patients with c-kit-negative tumors, 10 patients were positive for DOG1, PDGFR-α, or both. The most common primary site was stomach (44, 47.8%) followed by small bowel (17, 18.5%) and duodenum (14, 15.2%). Of 92 patients, 80 (87%) underwent R0 resection with organ sparing resection in 56 (70%) patients. Seventeen (21.3%) patients showed recurrence at a median follow-up of 6 years. Median and 5-year overall survival (OS) was 36 months (12–120) and 75%, respectively, and 5-year RFS was 81.8%. On univariate analysis, size, mitotic activity, malignant potential, and nuclear pleomorphism were predictors of recurrence. However, on multivariate analysis, only nuclear pleomorphism was significant. CONCLUSIONS: GISTs had a wide spectrum of presentation, and immunohistopathological features with organ sparing resection were conceivable in maximum. Nuclear pleomorphism may be considered as an important variable to predict recurrence in addition to malignant potential of tumors.en_US
dc.identifier.affiliationsDepartment of Gastrointestinal Surgery, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, Indiaen_US
dc.identifier.citationVarshney Vaibhav Kumar, Gupta Rakesh Kumar, Saluja Sundeep Singh, Tyagi Ila, Mishra Pramod Kumar, Batra Vineeta V. Analysis of clinicopathological and immunohistochemical parameters and correlation of outcomes in gastrointestinal stromal tumors. Indian Journal of Cancer. 2018 Apr; 56(2): 135-143en_US
dc.identifier.issn0019-509X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/190295
dc.languageenen_US
dc.publisherIndian Cancer Societyen_US
dc.relation.issuenumber2en_US
dc.relation.volume56en_US
dc.source.urihttps://dx.doi.org10.4103/ijc.IJC_352_18en_US
dc.titleAnalysis of clinicopathological and immunohistochemical parameters and correlation of outcomes in gastrointestinal stromal tumorsen_US
dc.typeJournal Articleen_US
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