Prevalence of antibodies to Leptospira serovars in rodents and shrews trapped in low and high endemic areas in Thailand.

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dc.contributor.authorKositanont, Uraiwanen_US
dc.contributor.authorNaigowit, Pimjaien_US
dc.contributor.authorImvithaya, Ampornen_US
dc.contributor.authorSingchai, Chantraen_US
dc.contributor.authorPuthavathana, Pilaipanen_US
dc.date.accessioned2009-05-27T18:58:04Z
dc.date.available2009-05-27T18:58:04Z
dc.date.issued2003-02-08en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To investigate the prevalence of antibodies to Leptospira serovars in rodents and shrews trapped in urban and rural areas in low and high endemic areas in Thailand. MATERIAL AND METHOD: A total of 1,664 serum samples were collected from rodents and shrews in areas of low and high endemicity for leptospirosis. Four areas classified by case rates (CR) per 100,000 population of leptospirosis were urban Area I Bangkok (CR = 0.07), rural Area II (CR = 0.24), rural Area III (CR = 1.97) and rural Area IV (CR = 48.20). All serum samples were investigated for antibodies to leptospires by microscopic agglutination test (MAT) using antigens from each of the 22 pathogenic serovars of Leptospira interrrogans: australis, autumnalis, ballum, bangkok, bataviae, bratislava, canicola, celledoni, copenhageni, djasiman, grippotyphosa, hardjo, hebdomadis, icterohaemorrhagiae, javanica, pomona, pyrogenes, rachmati, saigon, sejroe, tarassovi and wolffi and one non-pathogenic strain of L. biflexa serovar patoc. RESULTS: Ninety-four (5.6%) serum samples were positive for Leptospira antibodies. The most commonly detected antibodies were to serovars pyrogenes (39.1%), sejroe (19.1%), bataviae (10.0%), pomona (6.4%), autumnalis (5.5%), copenhageni (3.6%) and javanica (3.6%). The positive rates in Area I, II, III and IV were 7.6 per cent, 2.9 per cent, 4.6 per cent and 7.1 per cent, respectively. The seroprevalence in rural areas tended to increase significantly with high endemicity for leptospirosis (Chi-square for trend, p = 0.04). The seropositive rates by animal species were 39/496 (7.9%), 22/322 (6.8%), 23/492 (4.7%), 6/170 (3.5%), 4/175 (2.3%), 0/4 (0%) and 0/5 (0%) in Rattus norvegicus, Rattus exulans, Rattus rattus, Bandicota indica, Bandicota savilei, Mus musculus and Suncus murinus, respectively. There was a statistical trend between seropositive rates in R. exulans and endemicity for leptospirosis (Chi-square for trend, p = 0.04). CONCLUSION: The 5.6 per cent of rodents and shrews trapped in urban and rural areas in Thailand were reservoirs of leptospires. The results of high seroprevalence in rats also indicate the high endemicity for leptospirosis.en_US
dc.description.affiliationDepartment of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.en_US
dc.identifier.citationKositanont U, Naigowit P, Imvithaya A, Singchai C, Puthavathana P. Prevalence of antibodies to Leptospira serovars in rodents and shrews trapped in low and high endemic areas in Thailand. Journal of the Medical Association of Thailand. 2003 Feb; 86(2): 136-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40207
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAgglutination Testsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Bacterial --analysisen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshEndemic Diseases --statistics & numerical dataen_US
dc.subject.meshLeptospira --classificationen_US
dc.subject.meshLeptospirosis --epidemiologyen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProbabilityen_US
dc.subject.meshRatsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshRodent Diseases --epidemiologyen_US
dc.subject.meshRodentiaen_US
dc.subject.meshRural Populationen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.subject.meshShrewsen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshUrban Populationen_US
dc.titlePrevalence of antibodies to Leptospira serovars in rodents and shrews trapped in low and high endemic areas in Thailand.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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