Changes in bone histology due to capacitive electric field stimulation of ovariectomized rat.

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dc.contributor.authorJayanand
dc.contributor.authorBehari, Jitendra
dc.date.accessioned2011-12-16T09:36:11Z
dc.date.available2011-12-16T09:36:11Z
dc.date.issued2009-12
dc.description.abstractBackground & objectives: Postmenopausal osteoporosis leads to a significant decline in bone mass. That complicates the treatment outcome. The objective of the present study was to find out the effects of pulsed modulated low level electric field capacitively coupled on bone histology of induced osteoporotic rats, for screening the potential therapy for osteoporosis. Methods: Osteopororosis was induced by performed by bilateral ovariectomy of female Wistar rats. After one month of surgery electric field stimulation was delivered to one leg of experimatal rats while the other was sham exposed. After 60 days of exposure treated rats were sacrificed and femur and tibia bones were segregated into (i) control (CON), (ii) ovariectomized (OVX) and (iii) ovariectomized + electrical stimulation (OVX+ES). Results: Histopathological analyses showed that capacitively coupled pulsed electric field exposure treatment augmented and restored the bone marrow cell population. Immunohistological localization of alkaline phosphatase (ALP) showed the increased activity of this enzyme after electrostimulation, which showed an enhanced osteoblast differentiation. Collagen histochemistry showed high amount of collagen fiber in exposed rats bones than that of osteoporotic bones. Electron microscopic study revealed the enhancement of microstructural composition and compactness in cortical and trabecular part of treated bones. Interpretation & conclusions: Our results suggest that capacitively coupled pulsed electric field exposure treatment of specified parameters is efficacious in attenuating the effects of ovariectomy induced osteoporosis and restore the bone loss.en_US
dc.identifier.citationJayanand, Behari Jitendra. Changes in bone histology due to capacitive electric field stimulation of ovariectomized rat. Indian Journal of Medical Research. 2009 Dec; 130(6): 720-725.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135943
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2009/december/1208.pdfen_US
dc.subjectAlkaline phosphataseen_US
dc.subjectcapacitively coupleden_US
dc.subjectcollagenen_US
dc.subjectelectrical stimulationen_US
dc.subjectovariectomyen_US
dc.subjectpostmenopausal osteoporosisen_US
dc.subject.meshAlkaline Phosphatase --metabolism
dc.subject.meshAnimals
dc.subject.meshBone Marrow Cells --pathology
dc.subject.meshBone and Bones --metabolism
dc.subject.meshBone and Bones --pathology
dc.subject.meshCollagen --metabolism
dc.subject.meshDisease Models, Animal
dc.subject.meshElectric Stimulation Therapy --methods
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshOsteoporosis --metabolism
dc.subject.meshOsteoporosis --pathology
dc.subject.meshOsteoporosis --therapy
dc.subject.meshOvariectomy
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.titleChanges in bone histology due to capacitive electric field stimulation of ovariectomized rat.en_US
dc.typeArticleen_US
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