Transmembrane domains participate in functions of integral membrane proteins.

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dc.contributor.authorRamasarma, Ten_US
dc.date.accessioned1996-02-01en_US
dc.date.accessioned2009-05-27T09:26:33Z
dc.date.available1996-02-01en_US
dc.date.available2009-05-27T09:26:33Z
dc.date.issued1996-02-01en_US
dc.description25 references.en_US
dc.description.abstractIntegral membrane proteins have one or more transmembrane alpha-helical domains and carry out a variety of functions such as enzyme catalysis, transport across membranes, transducing signals as receptors of hormones and growth factors, and energy transfer in ATP synthesis. These transmembrane domains are not mere structural units anchoring the protein to the lipid bilayer but seem to-contribute in the overall activity. Recent findings in support of this are described using some typical examples-LDL receptor, growth factor receptor tyrosine kinase, HMG-CoA reductase, F0-ATPase and adrenergic receptors. The trends in research indicate that these transmembrane domains participate in a variety of ways such as a linker, a transducer or an exchanger in the overall functions of these proteins in transfer of materials, energy and signals.en_US
dc.description.affiliationDepartment of Biochemistry, Indian Institute of Science, Bangalore.en_US
dc.identifier.citationRamasarma T. Transmembrane domains participate in functions of integral membrane proteins. Indian Journal of Biochemistry & Biophysics. 1996 Feb; 33(1): 20-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27519
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEnzymes --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Proteins --chemistryen_US
dc.subject.meshModels, Structuralen_US
dc.subject.meshProtein Structure, Secondaryen_US
dc.subject.meshReceptors, Cell Surface --chemistryen_US
dc.titleTransmembrane domains participate in functions of integral membrane proteins.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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