Intraocular irrigating solutions. A clinical study of BSS Plus and dextrose bicarbonate fortified BSS as an infusate during pars plana vitrectomy.

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dc.contributor.authorSamuel, Michael Aen_US
dc.contributor.authorDesai, Uday Ren_US
dc.contributor.authorStrassman, Israelen_US
dc.contributor.authorAbusamak, Mohammeden_US
dc.date.accessioned2003-09-07en_US
dc.date.accessioned2009-05-29T09:12:44Z
dc.date.available2003-09-07en_US
dc.date.available2009-05-29T09:12:44Z
dc.date.issued2003-09-07en_US
dc.description.abstractPURPOSE: To compare the effect of Balanced Salt Solution Plus (BSS Plus, Alcon Laboratories, Fort Worth, Texas, USA) and fortified regular BSS on the cornea and lens, when used for continuous irrigation in pars plana vitrectomy (PPV) surgery. METHODS: Prospective, investigator masked, randomised study. Forty patients were randomly assigned to undergo PPV using BSS Plus (n=20) or fortified BSS (n=20) [regular BSS, fortified with 10.5 cc. of dextrose in water (D5W) and 13.1 cc. of 8.4% sodium bicarbonate]. Intraoperative features of the corneal epithelium, postoperative changes in the corneal endothelial cell denstiy (ECD) at 3 months, and clarity of the lens during surgery and postoperatively were evaluated. RESULTS: Intraoperative epithelial changes were similar in both groups with 7 (35%) of the cases having the epithelium removed in the BSS Plus group and 8 (40%) in the BSS fortified group (P=0.23). The mean differences in ECD (3 months versus preoperative) in the operated eyes when adjusted for changes in the control eye showed no difference with the type of BSS (P=0.98). Intraoperative lens changes were more significant (P=0.018) in the BSS fortified group. Postoperative lens status at 3 months was similar for both groups. Though there was a trend towards worse postoperative nuclear sclerosis change in the BSS fortified group, it was not significant (P=0.160). CONCLUSION: Standard BSS fortified with dextrose and bicarbonate is an efficacious infusion fluid during pars plana vitrectomy. Both solutions showed comparable effects on postoperative corneal endothelial cell density and corneal epithelial changes intraoperatively. BSS fortified has more lenticular changes intraoperatively than BSS Plus although no lens had to be removed in either group. The study implications are important since BSS fortified is significantly less expensive than BSS Plus.en_US
dc.description.affiliationHenry Ford Health System, Detroit, MI 48202, USA.en_US
dc.identifier.citationSamuel MA, Desai UR, Strassman I, Abusamak M. Intraocular irrigating solutions. A clinical study of BSS Plus and dextrose bicarbonate fortified BSS as an infusate during pars plana vitrectomy. Indian Journal of Ophthalmology. 2003 Sep; 51(3): 237-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/71343
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAcetates --administration & dosageen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBicarbonates --administration & dosageen_US
dc.subject.meshCell Counten_US
dc.subject.meshCornea --drug effectsen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucose --administration & dosageen_US
dc.subject.meshGlutathione --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshIntraoperative Perioden_US
dc.subject.meshIrrigation --methodsen_US
dc.subject.meshIsotonic Solutions --administration & dosageen_US
dc.subject.meshLens Implantation, Intraocular --methodsen_US
dc.subject.meshLens, Crystalline --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMinerals --administration & dosageen_US
dc.subject.meshOphthalmic Solutions --administration & dosageen_US
dc.subject.meshPostoperative Complicationsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSodium Chloride --administration & dosageen_US
dc.subject.meshVitrectomy --methodsen_US
dc.titleIntraocular irrigating solutions. A clinical study of BSS Plus and dextrose bicarbonate fortified BSS as an infusate during pars plana vitrectomy.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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