Fluoroquinolone resistance in bacterial isolates from ocular infections: Trend in antibiotic susceptibility patterns between 2005-2020

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dc.contributor.authorChatterjee, Samraten_US
dc.contributor.authorAgrawal, Deepshikhaen_US
dc.contributor.authorGomase, Sharad Nen_US
dc.contributor.authorParchand, Swapnil Men_US
dc.contributor.authorGangwe, Anil Ben_US
dc.contributor.authorMishra, Mihiren_US
dc.date.accessioned2023-08-25T06:35:32Z
dc.date.available2023-08-25T06:35:32Z
dc.date.issued2022-12
dc.description.abstractPurpose: To assess the fluoroquinolone resistance pattern and trends among bacterial isolates from ocular infections over a 16?year period and explore alternative antibiotics in fluoroquinolone?resistant strains. Methods: In this retrospective, longitudinal study, the microbiology laboratory records of patients with different ocular infections diagnosed at an eye institute in central India from 2005–2020 were reviewed to determine the pattern of fluoroquinolone (ciprofloxacin, ofloxacin, gatifloxacin, and moxifloxacin) resistance. Antibiotic susceptibility testing was done using the Kirby–Bauer disc diffusion method. Results: In 725 Gram?positive bacteria, the resistance of ciprofloxacin, ofloxacin, gatifloxacin, and moxifloxacin was 55.9% (95% confidence interval [CI]: 52.2 – 59.6), 42.7% (95% CI: 39.0 – 46.4), 47.6% (95% CI: 43.9 – 51.3), and 45.6% (95% CI: 41.7–49.5), respectively. In 266 Gram?negative bacteria, the resistance of ciprofloxacin, ofloxacin, gatifloxacin, and moxifloxacin was 57.9% (95% CI: 51.9 – 63.9), 56.0% (95% CI: 49.7 – 62.1), 59.9% (95% CI: 53.8 – 66.0), and 74.3% (95% CI: 68.3 – 80.2), respectively. A declining trend in resistance to ciprofloxacin (P < 0.001), ofloxacin (P < 0.001), and moxifloxacin (P < 0.001) was seen in Gram?positive bacteria, whereas a reduction in resistance to only moxifloxacin (P = 0.04) was seen in Gram?negative bacteria. In fluoroquinolone?resistant Gram?positive bacteria, cefuroxime exhibited the highest susceptibility, whereas in fluoroquinolone?resistant Gram?negative bacteria, colistin exhibited the highest susceptibility. Conclusion: Fluoroquinolone resistance was high among bacteria from ocular infections in central India, but a declining trend in resistance to some of the fluoroquinolones was observed in recent times. Cefuroxime and colistin emerged as alternatives in fluoroquinolone?resistant Gram?positive and Gram?negative bacterial infections, respectively.en_US
dc.identifier.affiliationsCornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsVitreo-Retina Services, MGM Eye Institute, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsOculoplasty and Ocular Oncology Services, MGM Eye Institute, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.citationChatterjee Samrat, Agrawal Deepshikha, Gomase Sharad N, Parchand Swapnil M, Gangwe Anil B, Mishra Mihir. Fluoroquinolone resistance in bacterial isolates from ocular infections: Trend in antibiotic susceptibility patterns between 2005-2020. Indian Journal of Ophthalmology. 2022 Dec; 70(12): 4391-4398en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224753
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber12en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1033_22en_US
dc.subjectAntibiotic resistanceen_US
dc.subjectbacteriaen_US
dc.subjectendophthalmitisen_US
dc.subjectfluoroquinoloneen_US
dc.subjectkeratitisen_US
dc.titleFluoroquinolone resistance in bacterial isolates from ocular infections: Trend in antibiotic susceptibility patterns between 2005-2020en_US
dc.typeJournal Articleen_US
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