Pulmonary manifestations in inflammatory bowel disease: a prospective study.
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Date
2011-09
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Abstract
Background Although pulmonary abnormalities have been recognized in patients with inflammatory bowel diseases (IBD), their prevalence and clinical significance are not
known.
Aim To study the prevalence and clinical significance of
pulmonary abnormalities in patients with IBD.
Methods Ninety-five non-consecutive patients with IBD
(12 Crohn’s disease, 83 ulcerative colitis; mean age 41.9
[SD 13] years; 47 women) were prospectively studied from
January 2007 to March 2010. Pulmonary function tests
(PFT) and high-resolution CT (HRCT) chest were performed
in them. PFT were compared to those in 270 healthy
(control) subjects matched for age, sex and smoking status.
Results Twenty-seven (28.5%) patients and 11 (4%) control
subjects had abnormal PFT (p<0.0001). Small airway
obstruction was seen in 18 patients, restrictive defect in
six and mixed defect in three. Twenty-one (22%) patients
had abnormal HRCT findings – bronchiectasis and nodules
(nine patients each, including one with nodules who later
developed active tuberculosis after infliximab therapy),
parenchymal bands (8), mediastinal lymphadenopathy
(five, including two with tuberculosis on histology and
culture), emphysema (5), brochiolitis (2), pleural effusion
or thickening (2), pericardial effusion (2), patchy consolidation
(1), ground-glass opacities (1) and lung metastasis
(1). Three patients had symptoms (one asthma, two cough).
Conclusion PFT and HRCT chest showed abnormality in
about one-quarter of patients with IBD. A majority of patients with these abnormalities were asymptomatic.
Description
Keywords
Diffusion abnormality, Interstitial lung disease, Lung function tests, Pulmonary involvement
Citation
Desai Devendra, Patil Samir, Udwadia Zarir, Maheshwari Shailendra, Abraham Philip, Joshi Anand. Pulmonary manifestations in inflammatory bowel disease: a prospective study. Indian Journal of Gastroenterology. 2011 Sept-Oct; 30(5): 225-228.