Long-term effect of interferon therapy on incidence of cirrhosis and hepatocellular carcinoma in Thai patients with chronic hepatitis B.

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dc.contributor.authorTangkijvanich, Pen_US
dc.contributor.authorThong-ngam, Den_US
dc.contributor.authorMahachai, Ven_US
dc.contributor.authorKladchareon, Nen_US
dc.contributor.authorSuwangool, Pen_US
dc.contributor.authorKullavanijaya, Pen_US
dc.date.accessioned2009-05-27T14:51:24Z
dc.date.available2009-05-27T14:51:24Z
dc.date.issued2001-09-12en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe aim of this study was to assess the long-term effects of interferon (IFN) therapy on the incidence of disease progression to cirrhosis and hepatocellular carcinoma (HCC) in Thai patients with chronic hepatitis B. Sixty-seven patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B who received IFN therapy were retrospectively analyzed. The average duration of follow-up was 59.4+/-30.9 months (ranging from 20 to 119 months). Seventy-two untreated patients with comparable clinical data and mean duration of follow-up served as a control group. During follow-up, 24 (35.8%) treated and 7 (9.7%) untreated patients had a sustained loss of HBeAg. However, none of the treated patients or controls became negative for hepatitis B s antigen (HBsAg). Among treated patients, the response was independent of type and dose of IFN, as well as the presence of steroid priming. In addition, 1 of 24 (4.2%) sustained responders and 6 of 43 (14%) non-responders progressed to cirrhosis whereas 16 of 72 (22.2%) in the control group progressed to such sequelae. The overall incidence of new cirrhosis in sustained responders was significantly lower than in the control group (p=0.04). HCC appeared in 11 cirrhotic patients: 9 (12.5%) in the control group and 2 (4.7%) of the non-responders, whereas none of the sustained responders developed HCC. The average period to detection of HCC was 70.5+/-12.4 months for non-responders and 65.3+/-27.6 months for the control group, with no significant differences between these groups. In conclusion, our data suggest that IFN therapy might prevent the progression of cirrhosis and the development of HCC in patients with chronic hepatitis B. These beneficial effects were particularly observed in those who achieved a sustained virological response to treatment.en_US
dc.description.affiliationDepartment of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationTangkijvanich P, Thong-ngam D, Mahachai V, Kladchareon N, Suwangool P, Kullavanijaya P. Long-term effect of interferon therapy on incidence of cirrhosis and hepatocellular carcinoma in Thai patients with chronic hepatitis B. The Southeast Asian Journal of Tropical Medicine and Public Health. 2001 Sep; 32(3): 452-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31270
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2001_32_3/02-2709.pdfen_US
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma, Hepatocellular --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B, Chronic --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInterferons --therapeutic useen_US
dc.subject.meshLiver Cirrhosis --epidemiologyen_US
dc.subject.meshLiver Neoplasms --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshTimeen_US
dc.titleLong-term effect of interferon therapy on incidence of cirrhosis and hepatocellular carcinoma in Thai patients with chronic hepatitis B.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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