Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids.

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dc.contributor.authorMargaret Shanthi, F Xen_US
dc.contributor.authorErnest, Kalpanaen_US
dc.contributor.authorDhanraj, Premaen_US
dc.date.accessioned2009-05-28T08:46:51Z
dc.date.available2009-05-28T08:46:51Z
dc.date.issued2008-07-18en_US
dc.description.abstractBACKGROUND: The calcium channel blocker, verapamil stimulates procollagenase synthesis in keloids and hypertrophic scars. AIM: To study the effect of verapamil in the treatment of hypertrophic scars and keloids and to evaluate the effect of verapamil on the rate of reduction of hypertrophic scars and keloids in comparison with triamcinolone. METHODS: The study was a randomized, single blind, parallel group study in which 54 patients were allocated to to receive either verapamil or triamcinolone. Drugs were administered intralesionally in both groups. Improvement of the scar was measured using modified Vancouver scale and by using a centimeter scale serially till the scar flattened. RESULTS: There was a reduction in vascularity, pliability, height and width of the scar with both the drugs after 3 weeks of treatment. These changes were present at one year of follow-up after stopping treatment. Scar pigmentation was not changed desirably by either drug. Length of the scars was also not altered significantly by either drug. The rate of reduction in vascularity, pliability, height and width of the scar with triamcinolone was faster than with verapamil. Adverse drug reactions were more with triamcinolone than with verapamil. CONCLUSION: Intralesional verapamil may be a suitable alternative to triamcinolone in the treatment of hypertrophic scars and keloids.en_US
dc.description.affiliationDepartment of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, India. drmaggi29@gmail.comen_US
dc.identifier.citationMargaret Shanthi FX, Ernest K, Dhanraj P. Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids. Indian Journal of Dermatology, Venereology and Leprology. 2008 Jul-Aug; 74(4): 343-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/53114
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCalcium Channel Blockers --administration & dosageen_US
dc.subject.meshChilden_US
dc.subject.meshCicatrix, Hypertrophic --drug therapyen_US
dc.subject.meshGlucocorticoids --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intralesionalen_US
dc.subject.meshKeloid --drug therapyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSingle-Blind Methoden_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshTriamcinolone Acetonide --administration & dosageen_US
dc.subject.meshVerapamil --administration & dosageen_US
dc.subject.meshYoung Adulten_US
dc.titleComparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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