Lactate dehydrogenase levels in preeclampsia and its correlation with maternal and perinatal outcome

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dc.contributor.authorGupta, Anjalien_US
dc.contributor.authorBhandari, Nirmalaen_US
dc.contributor.authorKharb, Simmien_US
dc.contributor.authorChauhan, Meenakshien_US
dc.date.accessioned2020-10-16T07:55:07Z
dc.date.available2020-10-16T07:55:07Z
dc.date.issued2019-04
dc.description.abstractBackground: Hypertensive disorder of pregnancy occurs in approximately 6-8% of all pregnancies. The most serious consequences for the mother and the baby are the result of preeclampsia and eclampsia. Lactate Dehydrogenase (LDH) is an intracellular enzyme. Recently LDH has been suggested as potential marker to predict severity of pre-eclampsia. The objective of the present study was to compare the serum lactate dehydrogenase levels in women with preeclampsia and normal pregnant women and to correlate lactate dehydrogenase levels with maternal and perinatal outcome in preeclampsia.Methods: An observational prospective study was conducted on 200 antenatal women attending the labour room emergency. Women with singleton pregnancy and cephalic presentation, from 28 weeks onwards were enrolled in the study. Out of 200, 100 were normal pregnant women and 100 were preeclamptic women. Serum LDH levels were measured in all women and maternal and perinatal outcome was assessed in terms of LDH levels.Results: Higher levels of LDH was observed in pregnant women with preeclampsia (627.38±230.04 IU/l) as compared to normal pregnant women (224.43±116.61 IU/l). The maternal complications were found to be maximum in women with LDH > 800 IU/l.  Abruption was the most common complication. The perinatal mortality and neonatal deaths were found to have significant correlation with high LDH levels.Conclusions: Maternal and perinatal complications were associated with higher LDH levels in preeclampsia patients. Serum LDH levels can be offered to all patients of preeclampsia and can be used to predict the prognosis of preeclampsia.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, Indiaen_US
dc.identifier.citationGupta Anjali, Bhandari Nirmala, Kharb Simmi, Chauhan Meenakshi. Lactate dehydrogenase levels in preeclampsia and its correlation with maternal and perinatal outcome. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2019 Apr; 8(4): 1505-1510en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206625
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20191208en_US
dc.subjectMaternal outcomeen_US
dc.subjectLactate dehydrogeneaseen_US
dc.subjectPreeclampsiaen_US
dc.subjectPerinatal outcomeen_US
dc.titleLactate dehydrogenase levels in preeclampsia and its correlation with maternal and perinatal outcomeen_US
dc.typeJournal Articleen_US
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