Impact of hepatitis C virus infection on renal transplant outcome in India--a single centre study.

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dc.contributor.authorAgarwal, S Ken_US
dc.contributor.authorDash, S Cen_US
dc.contributor.authorIrshad, Men_US
dc.contributor.authorGupta, Sen_US
dc.contributor.authorBhowmik, Den_US
dc.contributor.authorTiwari, S Cen_US
dc.contributor.authorGuleria, Sen_US
dc.contributor.authorMehta, S Nen_US
dc.date.accessioned2000-12-31en_US
dc.date.accessioned2009-05-30T20:59:13Z
dc.date.available2000-12-31en_US
dc.date.available2009-05-30T20:59:13Z
dc.date.issued2000-12-31en_US
dc.description.abstractBACKGROUND: Hepatitis C virus (HCV) infection is currently the main cause of hepatotropic viral infection in renal transplant (RT) recipient throughout the world. Contrary reports are available as regard graft and patient survival and liver disease outcome in these patients. From India, outcome of HCV positive patients following RT has not been documented. Herewith, we present results of RT in HCV positive patients at our centre. METHODS: Study design was prospective case control with primary end point being graft and patient survival and the exposure being HCV infection. Between June 1995 till February 1998, 128 patients had RT at our hospital, of which, 37 (28.9%) were anti-HCV positive at the time of RT. All the patients were on triple immunosuppressive therapy. As a policy of unit, none of the donor had HBV and/or HCV infection. Anti-HCV positive patients formed the subjects (Gr. I), while anti-HCV negative patients severed as control (Gr. II). Anti HCV was done using 3rd generation ELISA tests kit. HCV-RNA could not be done due to non-availability. None of the positive patient was treated with anti-viral therapy. Acute rejection, serious infections, patient and graft survival and outcome of liver disease was compared in these patients. RESULTS: Mean age of the patients, number of males, number of pre-RT haemodialysis and blood transfusion, donor age and HLA-mismatch were comparable in both the groups. Mean follow-up in Gr. I was 28 +/- 9.4 months and in Gr. II 31.4 +/- 7.6 months. At the end of this follow-up, acute rejection was seen in 43% and 33.3% patient in Gr. I and II respectively. In Gr. I, serious infections were seen in 30% while the same in Gr. II was 11.8% (p < 0.01). There was no difference in graft survival in Gr. I and II (72% and 66%) and the patient survival were also similar (72% and 66%). Of the deaths in Gr. I, 80% died of sepsis and 20% died of liver cell failure related to one each of hepatitis B and hepatitis E. Of the deaths in Gr. II, 65% died of sepsis and 17% died of hepatic cell failure. But, there was no difference in causes of deaths in these two groups. In both the groups, none of liver related death was due to isolated HCV infection. There was no effect of donor age, HLA mismatch, number of haemodialysis and pre-RT blood transfusion on the survival of graft as well as patient. CONCLUSION: In conclusion, HCV infection is major problem in RT with us. In a short follow-up of nearly 30 months, graft and patient survival is same in HCV positive and negative patients. However, serious infections are significantly more common in HCV positive patients.en_US
dc.description.affiliationDepartment of Nephrology, All India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationAgarwal SK, Dash SC, Irshad M, Gupta S, Bhowmik D, Tiwari SC, Guleria S, Mehta SN. Impact of hepatitis C virus infection on renal transplant outcome in India--a single centre study. Journal of the Association of Physicians of India. 2000 Dec; 48(12): 1155-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/88205
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshGraft Survivalen_US
dc.subject.meshHepacivirus --isolation & purificationen_US
dc.subject.meshHepatitis C --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshKidney Transplantation --adverse effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSurvival Analysisen_US
dc.titleImpact of hepatitis C virus infection on renal transplant outcome in India--a single centre study.en_US
dc.typeJournal Articleen_US
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