Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer.
dc.contributor.author | Wiwanitkit, V | |
dc.date.accessioned | 2013-01-15T04:59:02Z | |
dc.date.available | 2013-01-15T04:59:02Z | |
dc.date.issued | 2010-04 | |
dc.description.abstract | Background : Cell adhesion plays a pivotal role in diverse biological processes that occur in oncogenesis. BRCA1 was the first breast cancer susceptibility gene to be successfully identified and cloned. The role of BRCA1 as a predictive marker of chemotherapy response in breast cancer is proposed. Ligand binding is an important factor in the success of chemoprevention. Materials and Methods : In this work, the author performed a ligand-binding prediction for BRCA1 using a new bioinformatics tool. Results : According to this study, 10 strong possible ligands were identified. Conclusion : These sites can be useful for further drug development studies. | en_US |
dc.identifier.citation | Wiwanitkit V. Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer. Indian Journal of Cancer. 2010 Apr-June; 47(2): 139-141. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/144318 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2010;volume=47;issue=2;spage=139;epage=141;aulast=Wiwanitkit | en_US |
dc.subject | BRCA1 | en_US |
dc.subject | ligand binding | en_US |
dc.subject.mesh | BRCA1 Protein --metabolism | |
dc.subject.mesh | Breast Neoplasms --diagnosis | |
dc.subject.mesh | Breast Neoplasms --metabolism | |
dc.subject.mesh | Computational Biology | |
dc.subject.mesh | Drug Design | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | Tumor Markers, Biological --metabolism | |
dc.title | Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer. | en_US |
dc.type | Article | en_US |