The application of FTIR spectroscopy and chemometrics for classification of Mangosteen extract and its correlation with alpha-mangostin

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dc.contributor.authorRohman, Abdulen_US
dc.contributor.authorArifah, Fitriana Hayyuen_US
dc.contributor.authorIrnawatien_US
dc.contributor.authorAlam, Geminien_US
dc.contributor.authorMuchtaridi, Muchtaridien_US
dc.date.accessioned2020-10-16T08:56:54Z
dc.date.available2020-10-16T08:56:54Z
dc.date.issued2020-04
dc.description.abstractAlpha-mangostin is the major component in Mangosteen (Garcinia mangostana Linn) pericarp having severalpharmacological activities including reducing blood pressure, antidiabetic, anticancer, and antioxidants. The objectiveof this study was to develop Fourier transform infrared spectroscopy-multivariate calibration of partial least square(PLS) for quantitative analysis of alpha-mangostin and to classify mangosteen pericarp using principal componentanalysis. Mangosteen pericarps from different locations (Java provinces and South Sulawesi, Republic of Indonesia)were extracted using ethanol and were subjected to high performance liquid chromatography (HPLC) for the analysisof alpha-mangostin and Fourier transform infrared (FTIR) spectroscopy measurements. HPLC was used to determinethe levels of alpha-mangostin and used as actual values during FTIR spectroscopy analysis. The prediction of alphamangostin was obtained from the correlation between actual values and FTIR predicted values and facilitated withthe PLS model. The results showed that the wavenumbers region of 3,825–937 cm−1 offered a reliable model with acoefficient correlation (r) value of 0.9927 and root mean square error of calibration of 0.0831%. The validation modelsalso exhibited the accurate and precise results for the prediction of alpha-mangostin with an r-value of 0.9754 androot mean square error of prediction value of 0.174%. Furthermore, the chemometrics of principal component analysisusing variables of absorbances at selected fingerprint (1,000–800 cm−1) could classify mangosteen pericarp fromdifferent regions. FTIR spectroscopy combined with chemometrics offered a reliable method for quality assurance ofmangosteen pericarpen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesiaen_US
dc.identifier.affiliationsFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesiaen_US
dc.identifier.affiliationsFaculty of Pharmacy, Universitas Halu Oleo Kendari, Southeast Sulawesi 93232, Indonesiaen_US
dc.identifier.affiliationsFaculty of Pharmacy, Hasanuddin University, Makassar, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy Universitas Padjadjaran, Sumedang, Indonesiaen_US
dc.identifier.citationRohman Abdul, Arifah Fitriana Hayyu, Irnawati, Alam Gemini, Muchtaridi Muchtaridi. The application of FTIR spectroscopy and chemometrics for classification of Mangosteen extract and its correlation with alpha-mangostin. Journal of Applied Pharmaceutical Science. 2020 Apr; 2020 Apr: 149-154en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210740
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber4en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.104019en_US
dc.subjectAlpha-mangostinen_US
dc.subjectpartial least squareen_US
dc.subjectprincipal component analysisen_US
dc.subjectmangosteen pericarpen_US
dc.subjectFTIR spectroscopyen_US
dc.titleThe application of FTIR spectroscopy and chemometrics for classification of Mangosteen extract and its correlation with alpha-mangostinen_US
dc.typeJournal Articleen_US
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Journal of Applied Pharmaceutical Science (JAPS)