Investigating the potential of Bismuth vanadate to combat multidrug-resistant Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus
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Date
2025-06
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Publisher
Triveni Enterprises
Abstract
Aim: This study investigated the efficiency of BiVO nanoparticles (BiVO NPs) against drug-resistant bacteria, Acinetobacter baumannii and Methicillin-4 4 resistant Staphylococcus aureus (MRSA). Methodology: The study employed a multifaceted approach, evaluating the ablity of BiVO NPs to inhibit4 bacterial growth, reduce viable cell counts over time, and hinder biofilm formation. Furthermore, the investigation explored the NPs impact on virulence factors using protease and hemolysin inhibition assays. Results: The findings showed the potent efficacy of BiVO NPs against A. baumannii and MRSA. Notable4 results included the formation of clear inhibition zones up to 19 and 15 mm, indicating the antimicrobial activity against both pathogens. BiVO NPs also effectively4 inhibited biofilm formation, reduced bacterial adherence, and inhibited virulence factors, underscoring their potential as effective agents against drug-resistant bacteria and suggesting promising applications in medical implants and anti-microbial research. Interpretation: Overall, this study provides compelling evidence supporting the potential use of BiVO Nps as4 an antimicrobial agent and a promising candidate for addressing various human health concerns.
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Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore- 641 114, India, Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore- 641 114, India, Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore- 641 114, India, Department of Lifesciences, Kristu Jayanti College, Bengaluru- 560 077, India, Department of Applied Physics, Karunya Institute of Technology and Sciences, Coimbatore- 641114, India, Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore- 641 114, India
Citation
Aswathy V, Sajith S, Shakila R, Vijayanand S, Vidhya B, Murugan S. . Investigating the potential of Bismuth vanadate to combat multidrug-resistant Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus. Journal of Environmental Biology. 2025 Jun; 46(3): 349-356