Antipyrine clearance: prognostic marker for obstructive jaundice.

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dc.contributor.authorNazareth, H Men_US
dc.contributor.authorRege, N Nen_US
dc.contributor.authorNayak, V Ken_US
dc.contributor.authorDesai, N Ken_US
dc.contributor.authorSomeshwar, Ven_US
dc.contributor.authorDahanukar, S Aen_US
dc.contributor.authorBapat, R Den_US
dc.date.accessioned1990-01-01en_US
dc.date.accessioned2009-05-29T02:29:40Z
dc.date.available1990-01-01en_US
dc.date.available2009-05-29T02:29:40Z
dc.date.issued1990-01-01en_US
dc.description.abstractA prospective study was undertaken to determine prognostic markers for patients with obstructive jaundice. Along with routine liver function tests, antipyrine clearance was determined in 20 patients. Four patients died after basal investigations. Five patients underwent definitive surgery. The remaining 11 patients were subjected to percutaneous transhepatic biliary decompression. Four patients died during the drainage period, while surgery was carried out for seven patients within 1-3 weeks of drainage. Of 20 patients, only six patients survived. Basal liver function tests were comparable in survivors and nonsurvivors. Discriminant analysis of the basal data revealed that plasma bilirubin, proteins and antipyrine half-life taken together had a strong association with mortality. A mathematical equation was derived using these variables and a score was computed for each patient. It was observed that a score value greater than or equal to 0.84 indicated survival. Omission of antipyrine half-life from the data, however, resulted in prediction of false security in 55% of patients. This study highlights the importance of addition of antipyrine elimination test to the routine liver function tests for precise identification of high risk patients.en_US
dc.description.affiliationDepartment of Surgery, Seth G S Medical College, Parel, Bombay.en_US
dc.identifier.citationNazareth HM, Rege NN, Nayak VK, Desai NK, Someshwar V, Dahanukar SA, Bapat RD. Antipyrine clearance: prognostic marker for obstructive jaundice. Indian Journal of Gastroenterology. 1990 Jan; 9(1): 63-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64209
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntipyrine --pharmacokineticsen_US
dc.subject.meshCholestasis --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver --metabolismen_US
dc.subject.meshLiver Function Tests --methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.titleAntipyrine clearance: prognostic marker for obstructive jaundice.en_US
dc.typeJournal Articleen_US
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