Serum lipoprotein ratios as markers of insulin resistance: A study among non-diabetic acute coronary syndrome patients with impaired fasting glucose.

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dc.contributor.authorRay, S
dc.contributor.authorTalukdar, A
dc.contributor.authorSonthalia, N
dc.contributor.authorSaha, M
dc.contributor.authorKundu, S
dc.contributor.authorKhanra, D
dc.contributor.authorGuha, S
dc.contributor.authorBasu, A K
dc.contributor.authorMukherjee, A
dc.contributor.authorRay, D
dc.contributor.authorGanguly, S
dc.date.accessioned2015-06-26T04:25:09Z
dc.date.available2015-06-26T04:25:09Z
dc.date.issued2015-01
dc.description.abstractBackground & objectives: Recent data suggest that insulin resistance can predict cardiovascular disease independently of the other risk factors, such as hypertension, visceral obesity or dyslipidaemia. However, the majority of available methods to evaluate insulin resistance are complicated to operate, expensive, and time consuming. This study was undertaken to assess whether serum lipoprotein ratios could predict insulin resistance in non-diabetic acute coronary syndrome (ACS) patients. Methods: Ninety non-diabetic patients with impaired fasting glucose admitted with a diagnosis of ACS were included in the study. At the time of admission fasting glucose and insulin concentrations were measured. The homeostatic model assessment-insulin resistance (HOMA-IR) was used for insulin resistance. The fasting serum total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) levels were checked, and then TC/HDL-C and TG/HDL-C ratios were calculated. The areas under the curves (AUC) of the receiver operating characteristic (ROC) curves were used to compare the power of these serum lipoprotein ratios as markers. Results: Lipoprotein ratios were significantly higher in patients with HOMA-IR index > 2.5 as compared to patients with index <2.5 (P < 0.05). Both TG/HDL-C and TC/HDL-C ratios were significantly correlated with HOMA-IR (P<0.05). The area under the ROC curve of the TG/HDL-C and TC/HDL-C ratio for predicting insulin resistance was 0.80 (95% CI, 0.67 to 0.93), 0.78 (95% CI, 0.65 to 0.91), respectively. Interpretation & conclusions: The findings of this study demonstrate that serum lipoprotein ratios can provide a simple means of identifying insulin resistance and can be used as markers of insulin resistance and cardiovascular diseases risk in adult non-diabetic patients.en_US
dc.identifier.citationRay S, Talukdar A, Sonthalia N, Saha M, Kundu S, Khanra D, Guha S, Basu A K, Mukherjee A , Ray D, Ganguly S. Serum lipoprotein ratios as markers of insulin resistance: A study among non-diabetic acute coronary syndrome patients with impaired fasting glucose. Indian Journal of Medical Research. 2015 Jan; 141 (1): 62-67.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158404
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405942/?report=classicen_US
dc.subjectacute coronary syndromeen_US
dc.subjectfasting glucoseen_US
dc.subjectHDLen_US
dc.subjectCen_US
dc.subjectHOMAen_US
dc.subjectIRen_US
dc.subjectinsulin resistanceen_US
dc.subjectlipoprotein ratiosen_US
dc.subjectnon-diabeticen_US
dc.subjecttriglyceridesen_US
dc.subject.meshAcute Coronary Syndrome --complications
dc.subject.meshBiomarkers
dc.subject.meshBlood Glucose --analysis
dc.subject.meshBlood Glucose --blood
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshInsulin Resistance --physiology
dc.subject.meshLipoproteins --analysis
dc.subject.meshLipoproteins --blood
dc.subject.meshLipoproteins, HDL --analysis
dc.subject.meshLipoproteins, HDL --blood
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshTriglycerides --analysis
dc.subject.meshTriglycerides --blood
dc.titleSerum lipoprotein ratios as markers of insulin resistance: A study among non-diabetic acute coronary syndrome patients with impaired fasting glucose.en_US
dc.typeArticleen_US
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