AA Amyloidosis Secondary to Horton's Disease Complicated by Pulmonary Fibrosis: A Very Challenging Diagnosis and Therapy

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dc.contributor.authorNjie, Men_US
dc.contributor.authorMulendelé, P. Men_US
dc.contributor.authorMokni, Oen_US
dc.contributor.authorBoutar, M. Sen_US
dc.contributor.authorHaboub, Men_US
dc.contributor.authorArous, Sen_US
dc.contributor.authorBenouna, M. Gen_US
dc.contributor.authorDrighil, Aen_US
dc.contributor.authorAzzouzi, Len_US
dc.contributor.authorHabbal, R.en_US
dc.date.accessioned2023-07-21T11:29:42Z
dc.date.available2023-07-21T11:29:42Z
dc.date.issued2023-07
dc.description.abstractAA amyloidosis is a classic and serious complication of many chronic inflammatory processes, whether of infectious, autoimmune, or neoplastic origin. It is frequently complicated by kidney damage, often in the form of a nephrotic syndrome. Giant cell arteritis is a common inflammatory arteritis in the elderly; however, it rarely causes AA amyloidosis. We report a rare case of Horton disease causing AA amyloidosis in an elderly patient with history of myopericarditis and repeated episodes of congestive heart failure. Patient was treated initially with dual therapy based on corticosteroids and anti TNF therapy (Tocilizumab) associated with heart failure therapy recommended by the European society of cardiology (ESC 2021 guidelines on Heart Failure). The initial outcome was favorable but later complicated by the involvement of the lungs; pulmonary fibrosis, responsible for repeated episodes of pleural effusion non controlled in spite of high dose of loop diuretics and repeated pleural punction. Patient died shortly after her second hospitalization due to respiratory insufficiency.en_US
dc.identifier.affiliationsDepartment of Cardiology P37, Ibn Rochd University Hospital, Casablanca, Moroccoen_US
dc.identifier.affiliationsDepartment of Cardiology,PH, CH Jacques Monod, Normandie, Franceen_US
dc.identifier.affiliationsDepartment of Cardiology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.en_US
dc.identifier.citationNjie M, Mulendelé P. M, Mokni O, Boutar M. S, Haboub M, Arous S, Benouna M. G, Drighil A, Azzouzi L, Habbal R.. AA Amyloidosis Secondary to Horton's Disease Complicated by Pulmonary Fibrosis: A Very Challenging Diagnosis and Therapy. Cardiology and Angiology: An International Journal. 2023 Jul; 12(4): 144-153en_US
dc.identifier.issn2347-520X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220320
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.9734/ca/2023/v12i4353en_US
dc.subjectHorton diseaseen_US
dc.subjectAA amyloidosisen_US
dc.subjectpulmonary fibrosisen_US
dc.subjectCardiac MRIen_US
dc.subjectcorticosteroids and Tocilizumab.en_US
dc.titleAA Amyloidosis Secondary to Horton's Disease Complicated by Pulmonary Fibrosis: A Very Challenging Diagnosis and Therapyen_US
dc.typeJournal Articleen_US
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