Characteristics of treatment-naïve HBV-infected individuals with HIV-1 coinfection: A cross-sectional study from South India

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dc.contributor.authorDemosthenes, JPen_US
dc.contributor.authorSachithanandham, Jen_US
dc.contributor.authorFletcher, GJen_US
dc.contributor.authorZachariah, UGen_US
dc.contributor.authorVarghese, GMen_US
dc.contributor.authorJohn Daniel, HDen_US
dc.contributor.authorJeyaseelan, Len_US
dc.contributor.authorAbraham, Pen_US
dc.contributor.authorKannangai, Ren_US
dc.date.accessioned2020-04-23T07:38:07Z
dc.date.available2020-04-23T07:38:07Z
dc.date.issued2019-06
dc.description.abstractPurpose: Human immunodeficiency virus-1 (HIV-1) and hepatitis B virus (HBV) coinfection has become a major health problem across the globe. The increased life expectancy of HIV-1 patients due to antiretroviral therapy has led to the emergence of liver disease as a major mortality factor among them. The purpose of the study was to examine the baseline characteristics of HBV in treatment-naïve HBV/HIV coinfection from southern India compared to monoinfected individuals. Materials and Methods: The study was cross sectional in design, and samples were examined from 80 HIV-1, 70 HBV and 35 HBV/HIV-coinfected individuals using chemiluminescent microparticle immunoassay, real-time polymerase chain reaction and flow cytometry assays. Results: There was a significant increase in HBV DNA (P = 0.0001), higher hepatitis B e antigen percentage difference (P = 0.027) and lower CD4 counts (P = 0.01) among the HBV/HIV-coinfected individuals, but no difference in the HIV-1 viral load compared to HIV-1-monoinfected individuals. Also, the aspartate aminotransferase levels, prothrombin time and the international normalised ratio were significantly high among coinfected individuals. Conclusion: These findings conclude that HIV-1 coinfection can have serious implications on the outcome of HBV-related liver disease. To the contrary, HBV infection had no consequence on the progression of HIV-1 disease but distinctly lowered CD4+ T-cells.en_US
dc.identifier.affiliationsDepartment of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Hepatology, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.citationDemosthenes JP, Sachithanandham J, Fletcher GJ, Zachariah UG, Varghese GM, John Daniel HD, Jeyaseelan L, Abraham P, Kannangai R. Characteristics of treatment-naïve HBV-infected individuals with HIV-1 coinfection: A cross-sectional study from South India. Indian Journal of Medical Microbiology. 2019 Jun; 37(2): 219-224en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198862
dc.languageenen_US
dc.publisherIndian Association of Medical Microbiologistsen_US
dc.relation.issuenumber2en_US
dc.relation.volume37en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmm.IJMM_19_16en_US
dc.subjectAspartate aminotransferase to platelet ratio indexen_US
dc.subjectCD4 T cellen_US
dc.subjectfibrosis-4en_US
dc.subjecthepatitis B virusen_US
dc.subjecthuman immunodeficiency virus-1en_US
dc.subjectviral loaden_US
dc.titleCharacteristics of treatment-naïve HBV-infected individuals with HIV-1 coinfection: A cross-sectional study from South Indiaen_US
dc.typeJournal Articleen_US
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