Pharmacokinetic drug–drug interaction study between clindamycin and cyclosporin in rabbits

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dc.contributor.authorIssam, Mohammed Abushammalaen_US
dc.contributor.authorLama, Attef El Gusseinen_US
dc.contributor.authorBadea, Elzaman Zomloten_US
dc.contributor.authorKamal, Fakher Abushammallehen_US
dc.contributor.authorMohammed, Mahmoud Tahaen_US
dc.contributor.authorMohammed, Yousef Miqdaden_US
dc.date.accessioned2020-10-16T08:56:48Z
dc.date.available2020-10-16T08:56:48Z
dc.date.issued2020-02
dc.description.abstractCyclosporine A (CSA) is an immunosuppressant drug, metabolized mainly by CYP3A4 that is one of the CytochromeP450 enzymes. Clindamycin (CLN) is a lincosamide antibiotic, inducing CYP3A4 activity in vitro, and thereby mayalter CSA pharmacokinetics (PK). The current research was performed to investigate the PK parameters changes ofCSA up on co-administrating with CLN in healthy male rabbits. Twelve healthy male rabbits randomly were selectedand divided into two groups: Control set (n = 6) in which the rabbits were received oral normal saline CSA solution(10 mg/kg/day), meanwhile rabbits in the test group (n = 6) were treated with oral normal saline CSA solution (10 mg/kg/day) concomitantly with normal saline solution of CLN (8 mg/kg/day) at the same time for 7 days. Blood samples(2 ml) were collected and CSA concentrations were measured in whole blood at the predetermined time points byusing Chemiluminescent Immunoassay (CLIA) detection kit. PK profiles of CSA for both groups in the control andtest groups including Cmax, tmax, AUC0-24, the area under the blood concentration–time curve from 0 hour to infinity(AUC0-∞), t½, and Ke were compared. The results showed a statistically insignificant differences in the PK parametersof CSA alone or combined with CLN with p > 0.05. In conclusion, it has been found that CLN does not affect the CSAPK. Further confirmation of our findings is requiered in humans before these results can be applied in patient care.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al Azhar University Gaza, Gaza, Palestineen_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al Azhar University Gaza, Gaza, Palestine.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al Azhar University Gaza, Gaza, Palestine.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al Azhar University Gaza, Gaza, Palestine.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Faculty of Pharmacy, Al Azhar University Gaza, Gaza, Palestineen_US
dc.identifier.affiliationsCollege of Dentistry, Al Azhar University Gaza, Gaza, Palestine.en_US
dc.identifier.citationIssam Mohammed Abushammala, Lama Attef El Gussein, Badea Elzaman Zomlot, Kamal Fakher Abushammalleh, Mohammed Mahmoud Taha, Mohammed Yousef Miqdad. Pharmacokinetic drug–drug interaction study between clindamycin and cyclosporin in rabbits. Journal of Applied Pharmaceutical Science. 2020 Feb; 2020 Feb: 108-111en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210695
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber2en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.102016en_US
dc.subjectCyclosporineen_US
dc.subjectclindamycinen_US
dc.subjectdrug interactionen_US
dc.subjectpharmacokineticen_US
dc.subjectCYP3A4.en_US
dc.titlePharmacokinetic drug–drug interaction study between clindamycin and cyclosporin in rabbitsen_US
dc.typeJournal Articleen_US
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