Annual risk of tuberculosis infection in a rural population of South India and its relationship with prevalence of smear positive pulmonary tuberculosis.

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dc.contributor.authorChadha, V K
dc.contributor.authorAnjinappa, Sharada M
dc.contributor.authorGowda, Umadevi
dc.contributor.authorSrivastava, Ramesh
dc.contributor.authorAhmed, J
dc.contributor.authorKumar, Prahlad
dc.date.accessioned2015-07-17T11:56:42Z
dc.date.available2015-07-17T11:56:42Z
dc.date.issued2013-10
dc.description.abstractBackground: We conducted a tuberculin survey to estimate the annual risk of tuberculous infection (ARTI) among children in a sub-division of rural Bangalore district. A TB disease survey was conducted in the same area around the same time and has already been published. DOTS strategy is being implemented in the study area since 2002. Methods: The tuberculin survey was conducted during 2010-2011 among 3838, 5-9-year-old children attending 147 schools selected by simple random sampling. Children were tuberculin tested with 2TU PPD RT23 with Tween 80 and maximum diameter of induration was measured between 48-96 hours. ARTI was computed from prevalence of infection estimated by mirror-image technique. Prevalence of smear positive pulmonary TB estimated during the disease prevalence survey in 2008-10 was used to find out its relationship with ARTI. Results: Using the observed mode of tuberculin reaction sizes at 19 mm, among surveyed children, prevalence of infection was estimated at 7.3% (CI: 6.5-8.1); ARTI was computed at 1.05%. Considering the mean age of children, estimated ARTI most closely approximated to the year 2008. Every one per cent ARTI was found to correspond to a prevalence of 103 sputum smear positive patients of PTB, which was similar to the ratio of 106 found in the same study area during 1960s. Conclusion: There has been no change in the relationship between ARTI and prevalence of smear positive pulmonary TB from the pre-DOTS era and thus in the number of children infected by each adult point prevalent case of smear positive pulmonary TB each year suggesting the need for early case detection and treatment.en_US
dc.identifier.citationChadha V K , Anjinappa Sharada M, Gowda Umadevi, Srivastava Ramesh, Ahmed J, Kumar Prahlad. Annual risk of tuberculosis infection in a rural population of South India and its relationship with prevalence of smear positive pulmonary tuberculosis. Indian Journal of Tuberculosis. 2013 Oct; 60(4): 227-232.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159977
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ibr/t13/i4/ibrt13i4p227.pdfen_US
dc.subjectTuberculosisen_US
dc.subjectInfectionen_US
dc.subjectRisken_US
dc.subjectAnnualen_US
dc.subjectPrevalenceen_US
dc.subjectIndiaen_US
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshMycobacterium tuberculosis --epidemiology
dc.subject.meshMycobacterium tuberculosis --isolation & purification
dc.subject.meshPrevalence
dc.subject.meshRisk
dc.subject.meshRisk Assessment
dc.subject.meshRural Population
dc.subject.meshSputum --microbiology
dc.subject.meshTuberculosis, Pulmonary --epidemiology
dc.titleAnnual risk of tuberculosis infection in a rural population of South India and its relationship with prevalence of smear positive pulmonary tuberculosis.en_US
dc.typeArticleen_US
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