Is dietary fiber beneficial in chronic ischemic heart disease?

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dc.contributor.authorVajifdar, B Uen_US
dc.contributor.authorGoyal, V Sen_US
dc.contributor.authorLokhandwala, Y Yen_US
dc.contributor.authorMhamunkar, S Ren_US
dc.contributor.authorMahadik, S Pen_US
dc.contributor.authorGawad, A Ken_US
dc.contributor.authorHalankar, S Aen_US
dc.contributor.authorKulkarni, H Len_US
dc.date.accessioned2000-09-24en_US
dc.date.accessioned2009-05-30T19:09:08Z
dc.date.available2000-09-24en_US
dc.date.available2009-05-30T19:09:08Z
dc.date.issued2000-09-24en_US
dc.description.abstractOBJECTIVES: To evaluate the benefit of a dietary fiber preparation (Fibernat) in patients with chronic ischemic heart disease (IHD). METHODS: From January 1997 to March 1998, 114 consecutive patients with chronic IHD were enrolled in this prospective double blind randomized placebo controlled trial. The fiber (F) and placebo (P) groups were comparable at baseline. All patients were given advice regarding dietary and lifestyle modifications. Concomitant drug therapy was not altered. The drug (consisting of soluble and insoluble fibers obtained from fenugreek, guar gum and wheat bran) and placebo were administered for six months (10 grams twice daily). RESULTS: The following parameters improved in both groups: HDL cholesterol (32 to 39 mg/dl, p < 0.0009 in F and 33 to 38, p < 0.007 in P), total: HDL cholesterol ratio (6.7 to 5.6, p < 0.0007 in F and from 7.0 to 6.0, p < 0.01 in P) and weight (64.0 to 63.0 kg, p < 0.002 in F and 60.3 to 59.5, p < 0.002 in P). The Apolipoprotein B increased (101 to 129 mg/dl, p < 0.00001 in F and 98 to 127, p < 0.0008 in P). The following parameters improved only in group F: LDL cholesterol (146 to 134, p < 0.027), Apolipoprotein A-1 (105 to 139, p < 0.001), body mass index (24.9 to 24.5, p < 0.03) and waist circumference (37.2 to 36.7, p < 0.03). Total cholesterol, VLDL cholesterol, triglycerides, hip circumference, W:H ratio, exercise time and blood sugar were unchanged in both groups. CONCLUSIONS: Fibernat is well tolerated, safe and had favorable effects on LDL cholesterol, Apolipoprotein A-1, body mass index and waist circumference.en_US
dc.description.affiliationDepartment of Cardiology, KEM Hospital, Mumbai.en_US
dc.identifier.citationVajifdar BU, Goyal VS, Lokhandwala YY, Mhamunkar SR, Mahadik SP, Gawad AK, Halankar SA, Kulkarni HL. Is dietary fiber beneficial in chronic ischemic heart disease? Journal of the Association of Physicians of India. 2000 Sep; 48(9): 871-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/86509
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshApolipoprotein A-I --blooden_US
dc.subject.meshApolipoproteins B --blooden_US
dc.subject.meshBody Constitutionen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshCation Exchange Resinsen_US
dc.subject.meshCholesterol, HDL --blooden_US
dc.subject.meshCholesterol, LDL --blooden_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshDietary Fiber --adverse effectsen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Ischemia --blooden_US
dc.subject.meshProspective Studiesen_US
dc.titleIs dietary fiber beneficial in chronic ischemic heart disease?en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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